ENSDARG00000060316


Danio rerio

Features
Gene ID: ENSDARG00000060316
  
Biological name :cish
  
Synonyms : cish / cytokine inducible SH2-containing protein
  
Possible biological names infered from orthology : Q62225 / Q9NSE2
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 41503854
Gene end: 41506749
  
Corresponding Affymetrix probe sets: Dr.9911.1.A1_at (Zebrafish Array)   NM_001076617_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000079296
Ensembl peptide - ENSDARP00000121026
Ensembl peptide - ENSDARP00000116149
NCBI entrez gene - 767678     See in Manteia.
RefSeq - NM_001076617
RefSeq Peptide - NP_001070085
swissprot - E9QCT0
swissprot - E9QCE7
swissprot - Q08BW5
ZFIN ID - ZDB-GENE-050907-1
Ensembl - ENSDARG00000060316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CISHENSGALG00000002260Gallus gallus
 CISHENSG00000114737Homo sapiens
 CishENSMUSG00000032578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cishb / cytokine inducible SH2-containing protein b / CISH* / Q62225* / Q9NSE2* / cytokine inducible SH2 containing protein*ENSDARG0000001677348
socs2 / suppressor of cytokine signaling 2 / O14508* / O35717*ENSDARG0000004555733
socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*ENSDARG0000002542827
socs5b / suppressor of cytokine signaling 5b / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000006274525
socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*ENSDARG0000002661125
socs1a / suppressor of cytokine signaling 1a / SOCS1* / O35716* / O15524* / suppressor of cytokine signaling 1*ENSDARG0000003809525
socs4 / suppressor of cytokine signaling 4ENSDARG0000007850924
socs5a / suppressor of cytokine signaling 5a / SOCS5* / O75159* / O54928* / suppressor of cytokine signaling 5*ENSDARG0000010071724
socs7 / suppressor of cytokine signaling 7 / O14512*ENSDARG0000007701824
socs9 / suppressor of cytokine signaling 9ENSDARG0000010198524
socs6b / suppressor of cytokine signaling 6bENSDARG0000001586323
socs6a / suppressor of cytokine signaling 6a / SOCS6* / O14544* / suppressor of cytokine signaling 6*ENSDARG0000005856523
socs1b / suppressor of cytokine signaling 1bENSDARG0000008987322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028425  Cytokine-inducible SH2-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045620 negative regulation of lymphocyte differentiation IMP
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:1903707 negative regulation of hemopoiesis IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
Show

 ZFA:0000094 blood island blood island distended , abnormal
Show

 ZFA:0001078 thymus thymus lymphocyte increased amount , abnormal
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 ZFA:0005237 erythroblast erythroblast increased amount , abnormal
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 ZFA:0009021 common myeloid progenitor common myeloid progenitor increased distribution , abnormal
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 ZFA:0009046 T cell T cell increased amount , abnormal
Show

 ZFA:0009048 granulocyte granulocyte increased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased amount , abnormal
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 ZFA:0009265 monocyte monocyte increased amount , abnormal
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 ZFA:0009324 myeloid cell myeloid cell increased amount , abnormal
myeloid cell increased distribution , abnormal
Show

 ZFA:0009325 erythroid lineage cell erythroid lineage cell increased amount , abnormal
Show

 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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