ENSG00000114737


Homo sapiens

Features
Gene ID: ENSG00000114737
  
Biological name :CISH
  
Synonyms : CISH / cytokine inducible SH2 containing protein / Q9NSE2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.2
Gene start: 50606490
Gene end: 50611831
  
Corresponding Affymetrix probe sets: 221223_x_at (Human Genome U133 Plus 2.0 Array)   223377_x_at (Human Genome U133 Plus 2.0 Array)   223961_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000294173
Ensembl peptide - ENSP00000409346
NCBI entrez gene - 1154     See in Manteia.
OMIM - 602441
RefSeq - XM_011533329
RefSeq - NM_013324
RefSeq - NM_145071
RefSeq Peptide - NP_659508
RefSeq Peptide - NP_037456
swissprot - Q9NSE2
Ensembl - ENSG00000114737
  
Related genetic diseases (OMIM): 607948 - {Tuberculosis, susceptibility to}, 607948
  611162 - {Malaria, susceptibility to}, 611162
  614383 - {Bacteremia, susceptibility to}, 614383
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cishENSDARG00000060316Danio rerio
 cishbENSDARG00000016773Danio rerio
 CISHENSGALG00000002260Gallus gallus
 CishENSMUSG00000032578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083332
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067726
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG0000018455725
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG0000018533823
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421123
SOCS5 / O75159 / suppressor of cytokine signaling 5ENSG0000017115023
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028425  Cytokine-inducible SH2-containing protein
 IPR035887  CIS, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction NAS
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Neddylation
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex






 

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