ENSG00000171150


Homo sapiens

Features
Gene ID: ENSG00000171150
  
Biological name :SOCS5
  
Synonyms : O75159 / SOCS5 / suppressor of cytokine signaling 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p21
Gene start: 46698952
Gene end: 46763129
  
Corresponding Affymetrix probe sets: 208127_s_at (Human Genome U133 Plus 2.0 Array)   209647_s_at (Human Genome U133 Plus 2.0 Array)   209648_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305133
Ensembl peptide - ENSP00000378330
NCBI entrez gene - 9655     See in Manteia.
OMIM - 607094
RefSeq - NM_014011
RefSeq - NM_144949
RefSeq Peptide - NP_054730
RefSeq Peptide - NP_659198
swissprot - O75159
Ensembl - ENSG00000171150
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs5aENSDARG00000100717Danio rerio
 socs5bENSDARG00000062745Danio rerio
 SOCS5ENSGALG00000010016Gallus gallus
 Socs5ENSMUSG00000037104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOCS4 / Q8WXH5 / suppressor of cytokine signaling 4ENSG0000018000844
SOCS6 / O14544 / suppressor of cytokine signaling 6ENSG0000017067721
SOCS7 / O14512 / suppressor of cytokine signaling 7ENSG0000027421117
CISH / Q9NSE2 / cytokine inducible SH2 containing proteinENSG0000011473712
SOCS2 / O14508 / suppressor of cytokine signaling 2ENSG0000012083311
SOCS3 / O14543 / suppressor of cytokine signaling 3ENSG000001845579
SOCS1 / O15524 / suppressor of cytokine signaling 1ENSG000001853388


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR022252  SOCS4/SOCS5 domain
 IPR028420  Suppressor of cytokine signalling 5
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily
 IPR037343  SOCS5, SOCS box domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0009968 negative regulation of signal transduction NAS
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation ISS
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation ISS
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IEA
 biological_processGO:0097699 vascular endothelial cell response to fluid shear stress IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / reaction / complex
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction / complex
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

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