ENSG00000113520


Homo sapiens

Features
Gene ID: ENSG00000113520
  
Biological name :IL4
  
Synonyms : IL4 / interleukin 4 / P05112
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q31.1
Gene start: 132673986
Gene end: 132682676
  
Corresponding Affymetrix probe sets: 207538_at (Human Genome U133 Plus 2.0 Array)   207539_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480581
Ensembl peptide - ENSP00000231449
Ensembl peptide - ENSP00000325190
NCBI entrez gene - 3565     See in Manteia.
OMIM - 147780
RefSeq - NM_001354990
RefSeq - NM_000589
RefSeq - NM_172348
RefSeq Peptide - NP_758858
RefSeq Peptide - NP_000580
RefSeq Peptide - NP_001341919
swissprot - U3LVN1
swissprot - P05112
swissprot - Q5FC01
swissprot - D4HNR6
Ensembl - ENSG00000113520
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il4ENSMUSG00000000869Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001325  Interleukin-4/interleukin-13
 IPR002354  Interleukin-4
 IPR009079  Four-helical cytokine-like, core
 IPR018096  Interleukin-4/interleukin-13, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008203 cholesterol metabolic process ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030183 B cell differentiation TAS
 biological_processGO:0030890 positive regulation of B cell proliferation ISS
 biological_processGO:0032736 positive regulation of interleukin-13 production IDA
 biological_processGO:0035745 T-helper 2 cell cytokine production IDA
 biological_processGO:0042092 type 2 immune response TAS
 biological_processGO:0042102 positive regulation of T cell proliferation ISS
 biological_processGO:0042110 T cell activation IGI
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0042325 regulation of phosphorylation ISS
 biological_processGO:0043011 myeloid dendritic cell differentiation IDA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0045189 connective tissue growth factor biosynthetic process TAS
 biological_processGO:0045191 regulation of isotype switching TAS
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process ISS
 biological_processGO:0045582 positive regulation of T cell differentiation IDA
 biological_processGO:0045671 negative regulation of osteoclast differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes ISS
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes ISS
 biological_processGO:0050776 regulation of immune response ISS
 biological_processGO:0097028 dendritic cell differentiation IDA
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005136 interleukin-4 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000077238 IL4R / P24394 / interleukin 4 receptor  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex / reaction
 ENSG00000171150 SOCS5 / O75159 / suppressor of cytokine signaling 5  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / complex / reaction






 

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