ENSG00000077238


Homo sapiens

Features
Gene ID: ENSG00000077238
  
Biological name :IL4R
  
Synonyms : IL4R / interleukin 4 receptor / P24394
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.1
Gene start: 27313668
Gene end: 27364778
  
Corresponding Affymetrix probe sets: 203233_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461607
Ensembl peptide - ENSP00000461268
Ensembl peptide - ENSP00000486645
Ensembl peptide - ENSP00000170630
Ensembl peptide - ENSP00000379111
Ensembl peptide - ENSP00000441667
Ensembl peptide - ENSP00000454684
Ensembl peptide - ENSP00000454725
Ensembl peptide - ENSP00000455632
Ensembl peptide - ENSP00000455714
Ensembl peptide - ENSP00000456248
Ensembl peptide - ENSP00000456669
Ensembl peptide - ENSP00000456930
Ensembl peptide - ENSP00000457131
NCBI entrez gene - 3566     See in Manteia.
OMIM - 147781
RefSeq - XM_017023211
RefSeq - NM_001257406
RefSeq - NM_001257407
RefSeq - NM_001257997
RefSeq - XM_011545825
RefSeq - XM_011545826
RefSeq - XM_011545827
RefSeq - XM_011545828
RefSeq - XM_011545829
RefSeq - XM_011545830
RefSeq - XM_011545831
RefSeq - XM_011545832
RefSeq - XM_011545833
RefSeq - XM_011545834
RefSeq - NM_000418
RefSeq Peptide - NP_001244336
RefSeq Peptide - NP_001244926
RefSeq Peptide - NP_000409
RefSeq Peptide - NP_001244335
swissprot - I3L4W9
swissprot - J9JII2
swissprot - H3BRH7
swissprot - P24394
swissprot - Q5FC08
swissprot - A0A0G2JLA1
swissprot - H3BSE7
swissprot - H3BTD9
swissprot - I3L4H7
Ensembl - ENSG00000077238
  
Related genetic diseases (OMIM): 147050 - {Atopy, susceptibility to}, 147050
  609423 - {AIDS, slow progression to}, 609423
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000035447Gallus gallus
 Il4raENSMUSG00000030748Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015319  Interleukin-4 receptor alpha, N-terminal
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002532 production of molecular mediator involved in inflammatory response IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0035771 interleukin-4-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045626 negative regulation of T-helper 1 cell differentiation IEA
 biological_processGO:0045630 positive regulation of T-helper 2 cell differentiation IEA
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 biological_processGO:1990834 response to odorant IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004913 interleukin-4 receptor activity TAS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131724 P78552 / IL13RA1 / interleukin 13 receptor subunit alpha 1  / reaction / complex
 ENSG00000169194 IL13 / P35225 / interleukin 13  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000166888 STAT6 / P42226 / signal transducer and activator of transcription 6  / reaction / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000171150 SOCS5 / O75159 / suppressor of cytokine signaling 5  / reaction / complex
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000113520 IL4 / P05112 / interleukin 4  / reaction / complex






 

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