ENSMUSG00000000869


Mus musculus

Features
Gene ID: ENSMUSG00000000869
  
Biological name :Il4
  
Synonyms : Il4 / Interleukin-4 / P07750
  
Possible biological names infered from orthology : P05112
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 53602982
Gene end: 53618669
  
Corresponding Affymetrix probe sets: 10385832 (MoGene1.0st)   1449864_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134414
Ensembl peptide - ENSMUSP00000133617
Ensembl peptide - ENSMUSP00000000889
NCBI entrez gene - 16189     See in Manteia.
MGI - MGI:96556
RefSeq - NM_021283
RefSeq Peptide - NP_067258
swissprot - P07750
swissprot - G3UXB0
Ensembl - ENSMUSG00000000869
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL4ENSG00000113520Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001325  Interleukin-4/interleukin-13
 IPR002354  Interleukin-4
 IPR009079  Four-helical cytokine-like, core
 IPR018096  Interleukin-4/interleukin-13, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0002296 T-helper 1 cell lineage commitment IGI
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010633 negative regulation of epithelial cell migration ISO
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0031296 B cell costimulation IDA
 biological_processGO:0032736 positive regulation of interleukin-13 production ISO
 biological_processGO:0035745 T-helper 2 cell cytokine production ISO
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IDA
 biological_processGO:0042110 T cell activation ISO
 biological_processGO:0042113 B cell activation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043011 myeloid dendritic cell differentiation ISO
 biological_processGO:0043306 positive regulation of mast cell degranulation IMP
 biological_processGO:0045064 T-helper 2 cell differentiation IDA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IDA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IDA
 biological_processGO:0045582 positive regulation of T cell differentiation ISO
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048295 positive regulation of isotype switching to IgE isotypes IDA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050776 regulation of immune response IDA
 biological_processGO:0050868 negative regulation of T cell activation IDA
 biological_processGO:0050871 positive regulation of B cell activation IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0070351 negative regulation of white fat cell proliferation IDA
 biological_processGO:0097028 dendritic cell differentiation ISO
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:1903660 negative regulation of complement-dependent cytotoxicity ISO
 biological_processGO:2000320 negative regulation of T-helper 17 cell differentiation IDA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process ISO
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005136 interleukin-4 receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpe65tm1Lrcb/Rpe65tm1Lrcb
Genetic Background: 129S6/SvEvTac-Rpe65tm1Lrcb

 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000466 esophageal epithelium hyperplasia "increased cell number in the epithelial layer of the esophagus" [J:47225]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0000701 abnormal lymph node size "deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts
Genetic Background: involves: 129S7/SvEvBrd * DBA/1 * MRL/Mp

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.129-Ifngtm1Ts Tgfb1tm1Doe

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Stat6tm1Gru/Stat6tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Il4tm1(CD2)Mmrs/Il4tm1Lky
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002224 abnormal spleen size "deviation from the normal spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Defb1tm1Jmw/Defb1+
Genetic Background: B6.129S5-Defb1tm1Jmw

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl
Genetic Background: involves: 129 * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: C.129P2-Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4+
Genetic Background: C.129P2-Il4tm1.1Wep

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

Allelic Composition: Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic Background: involves: 129

Allelic Composition: Cigs2tm1.1Anse/Cigs2+,Il4tm1(CD2)Mmrs/Il4+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic Background: involves: 129

Allelic Composition: Cigs2tm1.1Anse/Cigs2+,Il4tm1(CD2)Mmrs/Il4+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.129P2-Il4tm1Cgn

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Cbltm1Ddlb/Cbl+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003278 esophageal inflammation "local accumulation of fluid, plasma proteins and leukocytes in the esophagus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pmp22tm1Lnot/Pmp22+
Genetic Background: Not Specified

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0004795 decreased anti-nuclear antigen antibody level "reduced level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: NOD.Cg-Il4tm1Cgn Tg(TcraBDC2.5,TcrbBDC2.5)1Doi

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

Allelic Composition: Il13tm1(YFP/cre)Lky/Il13+,Il4tm1(CD2)Mmrs/Il4+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc8a1tm1Yin/Slc8a1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.Cg-H2b Il4tm1Cgn

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: involves: C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129/Sv * 129X1/SvJ

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Lky/Il4tm1Lky,Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il4tm1Lky/Il4+,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1Sho/0,Itga5tm2Hyn/Itga5tm1Hyn,Itgavtm1Hyn/Itgavtm2Hyn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.129P2-Il4tm1Cgn

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.Cg-H2b Il4tm1Cgn

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2Rao/Il4tm2Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: C.129P2-Il4tm1.1Wep

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il2tm1Hor/Il2tm1Hor,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * NOD

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss

Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

Allelic Composition: Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic Background: involves: 129

Allelic Composition: Cigs2tm1.1Anse/Cigs2+,Il4tm1(CD2)Mmrs/Il4+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * MRL/Mp

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008697 decreased interleukin-3 secretion "reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells" [MESH:D12.644.276.374.410.240.400]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008698 abnormal interleukin-4 secretion "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: involves: C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il13tm1Anjm/Il13+,Il4tm1.1Wep/Il4+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Il4tm1Rao/Il4tm1Rao
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

Allelic Composition: Il4tm3.1Kubo/Il4tm3.1Kubo
Genetic Background: B6.Cg-Il4tm3.1Kubo

Allelic Composition: Fbn1Tsk/Fbn1+,Il4tm1Nnt/Il4tm1Nnt
Genetic Background: involves: C57BL/6 * C57BL/10 * DBA/2

Allelic Composition: Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic Background: involves: 129

Allelic Composition: Cigs2tm1.1Anse/Cigs2+,Il4tm1(CD2)Mmrs/Il4+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Il4tm1Nnt/Il4tm1Nnt
Genetic Background: C57BL/6-Il4tm1Nnt/J

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: C.129P2/OlaHsd-Il4/Il13tm3Anjm

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1.1Wep/Il4+,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep,Stat6tm1Gru/Stat6tm1Gru
Genetic Background: C.129-Stat6tm1Gru Il4tm1.1Wep

Allelic Composition: Il4tm1.1Wep/Il4tm1.1Wep
Genetic Background: C.129P2-Il4tm1.1Wep

Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129P2/OlaHsd * A/WySn * C57BL/10SnSg * Swiss

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: NOD.Cg-H2b Il4tm1Cgn

Allelic Composition: Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.129P2-Il4tm1Cgn

Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.Cg-Il4tm1Cgn Faslpr

 MP:0008896 increased IgG2c level "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm2.1Kubo/Il4tm2.1Kubo
Genetic Background: B6.Cg-Il4tm2.1Kubo

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0010215 abnormal circulating complement protein level "deviation from the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0010945 lung epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il4tm1Cgn/Il4tm1Cgn,Ndfip1Gt(RRD002)Byg/Ndfip1Gt(RRD002)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt,Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: C.Cg-Tgfb1tm1Doe Il4tm2Nnt

 MP:0030466 alveolar process atrophy "acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000037104 Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / reaction / complex
 ENSMUSG00000017057 O09030 / Il13ra1 / Interleukin-13 receptor subunit alpha-1 / P78552*  / reaction / complex






 

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