ENSMUSG00000031805


Mus musculus

Features
Gene ID: ENSMUSG00000031805
  
Biological name :Jak3
  
Synonyms : Jak3 / Janus kinase 3
  
Possible biological names infered from orthology : P52333
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 71676296
Gene end: 71690575
  
Corresponding Affymetrix probe sets: 10572693 (MoGene1.0st)   1423021_s_at (Mouse Genome 430 2.0 Array)   1425750_a_at (Mouse Genome 430 2.0 Array)   1427092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105640
Ensembl peptide - ENSMUSP00000060073
Ensembl peptide - ENSMUSP00000105639
NCBI entrez gene - 16453     See in Manteia.
MGI - MGI:99928
RefSeq - NM_001190830
RefSeq - NM_010589
RefSeq Peptide - NP_001177759
RefSeq Peptide - NP_034719
swissprot - A0A0R4J0R7
Ensembl - ENSMUSG00000031805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jak3ENSDARG00000010252Danio rerio
 JAK3ENSGALG00000033234Gallus gallus
 JAK3ENSG00000105639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jak2 / Janus kinase 2 / O60674*ENSMUSG0000002478949
Tyk2 / tyrosine kinase 2 / P29597*ENSMUSG0000003217540
Jak1 / Janus kinase 1 / P23458*ENSMUSG0000002853039


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020775  Tyrosine-protein kinase, non-receptor Jak3
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035771 interleukin-4-mediated signaling pathway IEA
 biological_processGO:0070670 response to interleukin-4 IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3+
Genetic Background: involves: 129S4/SvJae

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Alb+,Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Npy1rtm1Snby/Npy1rtm1Snby,Npy5rtm1Snby/Npy5rtm1Snby
Genetic Background: involves: 129 * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: P2ry2tm1Bhk/P2ry2tm1Bhk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Il7rtm1Imx/Il7rtm1Imx
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Mbd2tm1Bh/Mbd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atxn2tm2.1Geno/Atxn2tm2.1Geno
Genetic Background: B6.129S2-Atxn2tm2.1Geno

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irf7M2Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7M2Btlr

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Tks/Jak3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3+
Genetic Background: involves: 129S4/SvJae

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lfngtm1Grid/Lfngtm1Grid,Rfngtm1Grid/Rfngtm1Grid
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)1Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il7rtm1Imx/Il7rtm1Imx
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)1Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008046 absent NK cells "absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)1Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7rtm1Imx/Il7rtm1Imx
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Flv/Jak3tm1Flv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Jak3wil/Jak3wil
Genetic Background: C57BL/6JSfdAnu-Jak3wil/Anu

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0008121 increased myeloid dendritic cell number "greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Jak3tm1Ljb/Jak3+
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0008728 increased memory B cell number "greater number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0008729 decreased memory B cell number "reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: B6;129S4-Jak3tm1Ljb/J

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae

 MP:0009540 absent Hassall s corpuscle "absence of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Jak3M1Pgrs/Jak3M1Pgrs
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Jak3M1Pgrs/Jak3+
Genetic Background: involves: C57BL/6J * C57BL/10J

Allelic Composition: Jak3M1Pgrs/Jak3tm1Ljb
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/10J

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Jak3tm1Tks/Jak3tm1Tks
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Jak3m1Btlr/Jak3m1Btlr
Genetic Background: C57BL/6J-Jak3m1Btlr

Allelic Composition: Jak3m3Btlr/Jak3m3Btlr
Genetic Background: C57BL/6J-Jak3m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000869 Il4 / P07750 / Interleukin-4 / P05112*  / reaction / complex
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex / reaction
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / reaction / complex
 ENSMUSG00000026770 Il2ra / P01590 / interleukin 2 receptor, alpha chain / P01589* / interleukin 2 receptor subunit alpha*  / reaction / complex
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / complex / reaction
 ENSMUSG00000030745 Il21r / Q9JHX3 / Interleukin-21 receptor / Q9HBE5*  / complex
 ENSMUSG00000027718 Il21 / Q9ES17 / Interleukin-21 / Q9HBE4*  / complex
 ENSMUSG00000031712 Il15 / P48346 / Interleukin-15 / P40933*  / complex
 ENSMUSG00000030748 Il4ra / P16382 / Interleukin-4 receptor subunit alpha Soluble interleukin-4 receptor subunit alpha / IL4R* / P24394* / interleukin 4 receptor*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000023206 Il15ra / Q60819 / Interleukin-15 receptor subunit alpha Soluble interleukin-15 receptor subunit alpha / Q13261* / interleukin 15 receptor subunit alpha*  / complex
 ENSMUSG00000002147 Stat6 / P52633 / Signal transducer and transcription activator 6 / P42226* / signal transducer and activator of transcription 6*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / complex / reaction
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction






 

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