ENSMUSG00000040329


Mus musculus

Features
Gene ID: ENSMUSG00000040329
  
Biological name :Il7
  
Synonyms : Il7 / Interleukin-7 / P10168
  
Possible biological names infered from orthology : P13232
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: A1
Gene start: 7569994
Gene end: 7613760
  
Corresponding Affymetrix probe sets: 10497188 (MoGene1.0st)   1422080_at (Mouse Genome 430 2.0 Array)   1436861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126219
Ensembl peptide - ENSMUSP00000141508
Ensembl peptide - ENSMUSP00000141827
Ensembl peptide - ENSMUSP00000141845
NCBI entrez gene - 16196     See in Manteia.
MGI - MGI:96561
RefSeq - NM_001313890
RefSeq - NM_001313888
RefSeq - NM_001313889
RefSeq - NM_008371
RefSeq Peptide - NP_001300817
RefSeq Peptide - NP_001300818
RefSeq Peptide - NP_001300819
RefSeq Peptide - NP_032397
swissprot - P10168
swissprot - Q3UT18
swissprot - Q544C8
Ensembl - ENSMUSG00000040329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL7ENSG00000104432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000226  Interleukin-7/interleukin-9 family
 IPR001181  Interleukin-7
 IPR018049  Interleukin-7/Interleukin-9, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002360 T cell lineage commitment IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IGI
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0045453 bone resorption IDA
 biological_processGO:0045582 positive regulation of T cell differentiation IDA
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005139 interleukin-7 receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7tm1Hms/Il7tm1Hms
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dock2m3Btlr/Dock2m3Btlr
Genetic Background: C57BL/6J-Dock2m3Btlr

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

Allelic Composition: Il7tm1.1Mysl/Il7+
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il7tm1.1Mysl/Il7tm1.1Mysl
Genetic Background: B6.129P2(Cg)-Il7tm1.1Mysl

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr5a1tm1Klp/Nr5a1tm1Klp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Il7tm2.1Iku/Il7tm2.1Iku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Il2rgtm1Cgn/Y,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129-Rag2tm1Fwa Il2rgtm1Cgn

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Il7m1Jyen/Il7m1Jyen
Genetic Background: involves: C3H * C57BL/6

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0009624 small inguinal lymph nodes "reduced size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7hlb368/Il7hlb368
Genetic Background: C57BL/6J-Il7hlb368/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex






 

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