ENSG00000104432


Homo sapiens

Features
Gene ID: ENSG00000104432
  
Biological name :IL7
  
Synonyms : IL7 / interleukin 7 / P13232
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q21.13
Gene start: 78675743
Gene end: 78805523
  
Corresponding Affymetrix probe sets: 206693_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438922
Ensembl peptide - ENSP00000430272
Ensembl peptide - ENSP00000491060
Ensembl peptide - ENSP00000263851
Ensembl peptide - ENSP00000368408
Ensembl peptide - ENSP00000427750
Ensembl peptide - ENSP00000427800
Ensembl peptide - ENSP00000428364
NCBI entrez gene - 3574     See in Manteia.
OMIM - 146660
RefSeq - XM_017013397
RefSeq - NM_000880
RefSeq - NM_001199886
RefSeq - NM_001199887
RefSeq - NM_001199888
RefSeq - XM_011517522
RefSeq - XM_011517523
RefSeq Peptide - NP_001186816
RefSeq Peptide - NP_001186817
RefSeq Peptide - NP_000871
RefSeq Peptide - NP_001186815
swissprot - Q5FBY3
swissprot - Q5FBY6
swissprot - A0A0A0MTG5
swissprot - P13232
swissprot - Q5FBX5
Ensembl - ENSG00000104432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il7ENSMUSG00000040329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000226  Interleukin-7/interleukin-9 family
 IPR001181  Interleukin-7
 IPR018049  Interleukin-7/Interleukin-9, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IDA
 biological_processGO:0002360 T cell lineage commitment IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030890 positive regulation of B cell proliferation ISS
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045453 bone resorption ISS
 biological_processGO:0045582 positive regulation of T cell differentiation ISS
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005139 interleukin-7 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000168685 IL7R / P16871 / interleukin 7 receptor  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000147168 IL2RG / P31785 / interleukin 2 receptor subunit gamma  / reaction / complex
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex
 ENSG00000169047 IRS1 / P35568 / insulin receptor substrate 1  / complex
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / complex
 ENSG00000105639 JAK3 / P52333 / Janus kinase 3  / reaction / complex






 

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