ENSMUSG00000003882


Mus musculus

Features
Gene ID: ENSMUSG00000003882
  
Biological name :Il7r
  
Synonyms : Il7r / Interleukin-7 receptor subunit alpha / P16872
  
Possible biological names infered from orthology : interleukin 7 receptor / P16871
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 9505788
Gene end: 9530176
  
Corresponding Affymetrix probe sets: 10427628 (MoGene1.0st)   1448575_at (Mouse Genome 430 2.0 Array)   1448576_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003981
Ensembl peptide - ENSMUSP00000154530
NCBI entrez gene - 16197     See in Manteia.
MGI - MGI:96562
RefSeq - XM_017316439
RefSeq - NM_008372
RefSeq Peptide - NP_032398
RefSeq Peptide - NP_001342609
swissprot - P16872
Ensembl - ENSMUSG00000003882
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il7rENSDARG00000078970Danio rerio
 IL7RENSGALG00000013372Gallus gallus
 IL7RENSG00000168685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IGI
 biological_processGO:0001915 negative regulation of T cell mediated cytotoxicity IMP
 biological_processGO:0002377 immunoglobulin production IGI
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008361 regulation of cell size IGI
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0042100 B cell proliferation IMP
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:1904894 positive regulation of STAT cascade IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

Allelic Composition: Il7rtm1Imx/Il7rtm1Imx
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Il7rtm1Imx/Il7rtm1Imx,Tg(Lck-Il7r)1676Trma/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ikzf1tm3.1Mbu/Ikzf1tm3.1Mbu,Il7rtm1.1(icre)Hrr/Il7r+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lfngtm1Rjo/Lfngtm1Rjo,Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA * ICR

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Tg(Mnx1-EGFP)#Tmj/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Il7rtm1Imx/Il7rtm1Imx
Genetic Background: B6.129S7-Il7rtm1Imx

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Il7rtm1Imx/Il7rtm1Imx,Tg(Lck-Il7r)1676Trma/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Abra/Il7rtm1Abra
Genetic Background: B6.129S4-Il7rtm1Abra

Allelic Composition: Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Il4ratm1Sz/Il4ratm1Sz,Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6

Allelic Composition: Il15tm1Imx/Il15tm1Imx,Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Il7rtm1.1Asin/Il7rtm1Imx,Tg(Cd8a*-cre)#Asin/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr5a1tm2Klp/Nr5a1tm2Klp,Tg(Cga-cre)3Sac/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Rdh10tm1c(KOMP)Wtsi/Rdh10tm1c(KOMP)Wtsi,Tg(Amh-cre)8815Reb/0,Tg(RARE-Hspa1b/lacZ)12Jrt/0,Tg(Stra8-icre)1Reb/0
Genetic Background: involves: C57BL/6 * C57BL/6N * CD-1 * FVB/N * SJL

 MP:0008355 absent mature gamma-delta T cells "absence of a mature T cell expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008356 abnormal gamma-delta T cell differentiation "atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Il7rtm1Iku/Il7rtm1Iku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il7rtm1Imx/Il7rtm1Imx,Tg(Lck-Il7r)1676Trma/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040329 Il7 / P10168 / Interleukin-7 / P13232*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / reaction / complex
 ENSMUSG00000024379 Tslp / Q9JIE6 / Thymic stromal lymphopoietin / Q969D9*  / complex
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSMUSG00000033467 Crlf2 / cytokine receptor-like factor 2 isoform 1 / Q9HC73* / cytokine receptor like factor 2*  / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex






 

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