ENSMUSG00000024379


Mus musculus

Features
Gene ID: ENSMUSG00000024379
  
Biological name :Tslp
  
Synonyms : Q9JIE6 / Thymic stromal lymphopoietin / Tslp
  
Possible biological names infered from orthology : Q969D9
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B1
Gene start: 32815383
Gene end: 32819799
  
Corresponding Affymetrix probe sets: 10454601 (MoGene1.0st)   1450004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025237
NCBI entrez gene - 53603     See in Manteia.
MGI - MGI:1855696
RefSeq - NM_021367
RefSeq Peptide - NP_067342
swissprot - Q9JIE6
Ensembl - ENSMUSG00000024379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSLPENSG00000145777Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029189  Thymic stromal lymphopoietin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway ISO
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032733 positive regulation of interleukin-10 production ISO
 biological_processGO:0032736 positive regulation of interleukin-13 production ISO
 biological_processGO:0032754 positive regulation of interleukin-5 production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0033005 positive regulation of mast cell activation ISO
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0044140 negative regulation of growth of symbiont on or near host surface ISO
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050829 defense response to Gram-negative bacterium ISO
 biological_processGO:0050832 defense response to fungus ISO
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide ISO
 biological_processGO:0071654 positive regulation of chemokine (C-C motif) ligand 1 production ISO
 biological_processGO:0071657 positive regulation of granulocyte colony-stimulating factor production ISO
 biological_processGO:1904894 positive regulation of STAT cascade ISO
 biological_processGO:2000664 positive regulation of interleukin-5 secretion ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005139 interleukin-7 receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx4M1Yzcm/Alx4M1Yzcm
Genetic Background: C57BL/6-Alx4M1Yzcm

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Alx4M1Yzcm/Alx4M1Yzcm
Genetic Background: C57BL/6-Alx4M1Yzcm

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Rag1tm1.1Sadu/Rag1tm1.1Sadu,Trdctm1Mal/Trdctm1Mal,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Alx4M1Yzcm/Alx4M1Yzcm
Genetic Background: C57BL/6-Alx4M1Yzcm

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Alx4M1Yzcm/Alx4M1Yzcm
Genetic Background: C57BL/6-Alx4M1Yzcm

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef1a1tm1(Kras*)Arge/Eef1a1+,Igf1rtm2Arge/Igf1rtm2Arge,Waptm1(cre)Arge/Wap+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Tslptm1.2Pcn/Tslptm1.2Pcn
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Tslptm1.1Pcn/Tslptm1.1Pcn,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lin28atm1Gqda/Lin28atm1Gqda,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003882 Il7r / P16872 / Interleukin-7 receptor subunit alpha / P16871* / interleukin 7 receptor*  / complex
 ENSMUSG00000033467 Crlf2 / cytokine receptor-like factor 2 isoform 1 / Q9HC73* / cytokine receptor like factor 2*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex






 

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