ENSG00000145777


Homo sapiens

Features
Gene ID: ENSG00000145777
  
Biological name :TSLP
  
Synonyms : Q969D9 / thymic stromal lymphopoietin / TSLP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q22.1
Gene start: 111070062
Gene end: 111078024
  
Corresponding Affymetrix probe sets: 235737_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427827
Ensembl peptide - ENSP00000339804
Ensembl peptide - ENSP00000399099
NCBI entrez gene - 85480     See in Manteia.
OMIM - 607003
RefSeq - XM_011543698
RefSeq - NM_033035
RefSeq - NM_138551
RefSeq Peptide - NP_149024
RefSeq Peptide - NP_612561
swissprot - Q969D9
swissprot - A0A0C4DG43
Ensembl - ENSG00000145777
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TslpENSMUSG00000024379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR029189  Thymic stromal lymphopoietin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IDA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032736 positive regulation of interleukin-13 production IMP
 biological_processGO:0032754 positive regulation of interleukin-5 production IMP
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0033005 positive regulation of mast cell activation IMP
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0071654 positive regulation of chemokine (C-C motif) ligand 1 production IMP
 biological_processGO:0071657 positive regulation of granulocyte colony-stimulating factor production IMP
 biological_processGO:1904894 positive regulation of STAT cascade IDA
 biological_processGO:2000664 positive regulation of interleukin-5 secretion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IMP
 molecular_functionGO:0005139 interleukin-7 receptor binding IMP


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000168685 IL7R / P16871 / interleukin 7 receptor  / complex
 ENSG00000205755 CRLF2 / Q9HC73 / cytokine receptor like factor 2  / complex






 

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