ENSMUSG00000021538


Mus musculus

Features
Gene ID: ENSMUSG00000021538
  
Biological name :Il9
  
Synonyms : Il9 / Interleukin-9 / P15247
  
Possible biological names infered from orthology : P15248
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56479277
Gene end: 56482246
  
Corresponding Affymetrix probe sets: 10409586 (MoGene1.0st)   1450565_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022019
NCBI entrez gene - 16198     See in Manteia.
MGI - MGI:96563
RefSeq - NM_008373
RefSeq Peptide - NP_032399
swissprot - P15247
Ensembl - ENSMUSG00000021538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL9ENSG00000145839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000226  Interleukin-7/interleukin-9 family
 IPR018049  Interleukin-7/Interleukin-9, conserved site
 IPR020447  Interleukin-9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0045407 positive regulation of interleukin-5 biosynthetic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000359 abnormal mast cell morphology "anomalous structure of these granulated cells found in most tissues, but most abundantly in skin and g.i. tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il9tm1Flv/Il9tm1Flv
Genetic Background: BALB/c-Il9tm1Flv

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm3Anjm/Il5tm3Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il9tm1Flv/Il9tm1Flv
Genetic Background: BALB/c-Il9tm1Flv

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il5tm1Anjm/Il5tm1Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il5tm2Anjm/Il5tm2Anjm,Il9tm1Anjm/Il9tm1Anjm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000020279 Il9r / Q01114 / Interleukin-9 receptor / Q01113*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction






 

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