ENSMUSG00000020279


Mus musculus

Features
Gene ID: ENSMUSG00000020279
  
Biological name :Il9r
  
Synonyms : Il9r / Interleukin-9 receptor / Q01114
  
Possible biological names infered from orthology : Q01113
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A4
Gene start: 32187541
Gene end: 32200279
  
Corresponding Affymetrix probe sets: 10384974 (MoGene1.0st)   1421570_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119557
Ensembl peptide - ENSMUSP00000020518
Ensembl peptide - ENSMUSP00000118204
Ensembl peptide - ENSMUSP00000119185
NCBI entrez gene - 16199     See in Manteia.
MGI - MGI:96564
RefSeq - XM_017314298
RefSeq - NM_008374
RefSeq - XM_006514533
RefSeq - XM_006514534
RefSeq - XM_006514537
RefSeq - XM_006514538
RefSeq - XM_006514539
RefSeq - XM_006514540
RefSeq - NM_001134458
RefSeq Peptide - NP_032400
RefSeq Peptide - NP_001127930
swissprot - Q78PA5
swissprot - F8WJ69
swissprot - Q01114
swissprot - A2AVE0
swissprot - B7ZD65
Ensembl - ENSMUSG00000020279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006394Gallus gallus
 IL9RENSG00000124334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Spry2tm1Mrt/Spry2tm1Mrt
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / reaction / complex
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / complex / reaction
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / complex / reaction
 ENSMUSG00000021538 Il9 / P15247 / Interleukin-9 / P15248*  / complex / reaction






 

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