ENSDARG00000010252


Danio rerio

Features
Gene ID: ENSDARG00000010252
  
Biological name :jak3
  
Synonyms : jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte)
  
Possible biological names infered from orthology : Janus kinase 3 / P52333
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 13389115
Gene end: 13412597
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000129749
Ensembl peptide - ENSDARP00000049468
Ensembl peptide - ENSDARP00000154620
NCBI entrez gene - 561370     See in Manteia.
swissprot - B0V237
swissprot - X1WHN6
ZFIN ID - ZDB-GENE-070725-4
Ensembl - ENSDARG00000010252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JAK3ENSGALG00000033234Gallus gallus
 JAK3ENSG00000105639Homo sapiens
 Jak3ENSMUSG00000031805Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*ENSDARG0000001888247
jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*ENSDARG0000010480847
tyk2 / tyrosine kinase 2 / P29597*ENSDARG0000002032638
jak1 / Janus kinase 1 / P23458*ENSDARG0000002062538


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-7 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001078 thymus thymus hypoplastic , abnormal
thymus cellularity , abnormal
thymus lacks parts or has fewer parts of type pro-T cell , abnormal
thymus decreased amount , abnormal
Show

 ZFA:0009350 pro-T cell pro-T cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex
 ENSDARG00000069961 il21r.1 / interleukin 21 receptor, tandem duplicate 1 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000078970 il7r / interleukin 7 receptor / P16871* / P16872* / Interleukin-7 receptor subunit alpha *  / complex
 ENSDARG00000075282 irs2b / insulin receptor substrate 2b / IRS2* / Irs3* / P81122* / Q9Y4H2* / insulin receptor substrate 2*  / complex
 ENSDARG00000068858 il2rga / interleukin 2 receptor, gamma a / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex / reaction
 ENSDARG00000053702 il2rgb / interleukin 2 receptor, gamma b / IL2RG* / P34902* / P31785* / Gm20489* / AL590764.2* / interleukin 2 receptor subunit gamma* / Cytokine receptor common subunit gamma *  / complex / reaction
 ENSDARG00000078649 il21r.2 / interleukin 21 receptor, tandem duplicate 2 / IL21R* / Q9JHX3* / Q9HBE5* / interleukin 21 receptor*  / complex
 ENSDARG00000054087 irs1 / insulin receptor substrate 1 / P35568*  / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex






 

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