ENSDARG00000020326


Danio rerio

Features
Gene ID: ENSDARG00000020326
  
Biological name :tyk2
  
Synonyms : tyk2 / tyrosine kinase 2
  
Possible biological names infered from orthology : P29597
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 46479705
Gene end: 46555542
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124187
Ensembl peptide - ENSDARP00000152966
NCBI entrez gene - 100536675     See in Manteia.
RefSeq - XM_003198153
RefSeq - XM_005164236
RefSeq - XM_009299743
swissprot - F8W4H3
ZFIN ID - ZDB-GENE-071116-4
Ensembl - ENSDARG00000020326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TYK2ENSG00000105397Homo sapiens
 Tyk2ENSMUSG00000032175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jak1 / Janus kinase 1 / P23458*ENSDARG0000002062544
jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*ENSDARG0000010480837
jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*ENSDARG0000001888237
jak3 / Janus kinase 3 (a protein tyrosine kinase, leukocyte) / P52333* / Janus kinase 3*ENSDARG0000001025236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR016045  Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
 IPR016251  Tyrosine-protein kinase, non-receptor Jak/Tyk2
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-20 family signaling
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / complex
 ENSDARG00000052157 il12rb2 / interleukin 12 receptor, beta 2a / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / complex
 ENSDARG00000020625 jak1 / Janus kinase 1 / P23458*  / complex
 ENSDARG00000028731 stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSDARG00000078147 il10 / interleukin 10 / P18893* / P22301*  / complex
 ENSDARG00000020334 ptpn11a / protein tyrosine phosphatase, non-receptor type 11, a / PTPN11* / P35235* / Q06124* / Tyrosine-protein phosphatase non-receptor type 11 * / protein tyrosine phosphatase, non-recep...  / reaction / complex
 ENSDARG00000099342 crfb15 / cytokine receptor family member B15 / Q08334* / IL10RB* / Gm21970* / interleukin 10 receptor subunit beta*  / complex / reaction
 ENSDARG00000104693 il6st / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / complex
 ENSDARG00000078042 il10rb / interleukin 10 receptor, beta / P33896* / IFNAR1* / P17181* / Interferon alpha/beta receptor 1 * / interferon alpha and beta receptor subunit 1*  / complex
 ENSDARG00000032571 il20ra / interleukin 20 receptor, alpha / Q6PHB0* / Q9UHF4* / interleukin 20 receptor subunit alpha*  / complex
 ENSDARG00000020326 tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr