ENSMUSG00000026770


Mus musculus

Features
Gene ID: ENSMUSG00000026770
  
Biological name :Il2ra
  
Synonyms : Il2ra / interleukin 2 receptor, alpha chain / P01590
  
Possible biological names infered from orthology : interleukin 2 receptor subunit alpha / P01589
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A1
Gene start: 11642807
Gene end: 11693193
  
Corresponding Affymetrix probe sets: 10469278 (MoGene1.0st)   1420691_at (Mouse Genome 430 2.0 Array)   1420692_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028111
Ensembl peptide - ENSMUSP00000141881
NCBI entrez gene - 16184     See in Manteia.
MGI - MGI:96549
RefSeq - NM_008367
RefSeq Peptide - NP_032393
swissprot - P01590
swissprot - Q3THW2
swissprot - Q544I2
Ensembl - ENSMUSG00000026770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL2RAENSG00000134460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR015486  Interleukin-2 receptor alpha
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002437 inflammatory response to antigenic stimulus IEA
 biological_processGO:0002664 regulation of T cell tolerance induction IEA
 biological_processGO:0006924 activation-induced cell death of T cells IMP
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007219 Notch signaling pathway IGI
 biological_processGO:0038110 interleukin-2-mediated signaling pathway IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043029 T cell homeostasis IMP
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0046013 regulation of T cell homeostatic proliferation IMP
 biological_processGO:0050672 negative regulation of lymphocyte proliferation IMP
 biological_processGO:0050687 negative regulation of defense response to virus IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050777 negative regulation of immune response IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004911 interleukin-2 receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0019976 interleukin-2 binding IEA


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
Interleukin-2 signaling
Interleukin receptor SHC signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Faslpr/Faslpr,Il2ratm1Dw/Il2ratm1Dw,Tg(CD2-Ccdc86)1Hfuj/?
Genetic Background: B6.Cg-Il2ratm1Dw Faslpr Tg(CD2-Ccdc86)1Hfuj

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Tg(Prnp*A116V*M128V)1309Jama/0
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc2tm1Plob/Npc2tm1Plob
Genetic Background: C.129S1-Npc2tm1Plob

Allelic Composition: Il2ratm1Dw/Il2ratm1Dw,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2ratm1Dw Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2ratm1Dw/Il2ratm1Dw,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2ratm1Dw Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il2ratm1Dw/Il2ratm1Dw,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2ratm1Dw Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin,Il2ratm1Dw/Il2ratm1Dw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin,Il2ratm1Dw/Il2ratm1Dw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Roml/Il1r1tm1Roml
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

 MP:0009517 abnormal salivary gland duct morphology "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nebtm2Hgra/Nebtm2Hgra,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S6/SvEvTac * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031805 Jak3 / Janus kinase 3 / P52333*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000031304 Il2rg / P34902 / Cytokine receptor common subunit gamma / P31785* / AL590764.2* / interleukin 2 receptor subunit gamma*  / reaction / complex
 ENSMUSG00000068227 Il2rb / P16297 / Interleukin-2 receptor subunit beta / P14784*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000027720 Il2 / P04351 / Interleukin-2 / P60568*  / reaction / complex






 

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