ENSG00000171855


Homo sapiens

Features
Gene ID: ENSG00000171855
  
Biological name :IFNB1
  
Synonyms : IFNB1 / interferon beta 1 / P01574
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p21.3
Gene start: 21077105
Gene end: 21077963
  
Corresponding Affymetrix probe sets: 208173_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369581
NCBI entrez gene - 3456     See in Manteia.
OMIM - 147640
RefSeq - NM_002176
RefSeq Peptide - NP_002167
swissprot - P01574
Ensembl - ENSG00000171855
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ifnb1ENSMUSG00000048806Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IFNE / Q86WN2 / interferon epsilonENSG0000018499537


Protein motifs (from Interpro)
Interpro ID Name
 IPR000471  Interferon alpha/beta/delta
 IPR009079  Four-helical cytokine-like, core
 IPR015588  Interferon beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IBA
 biological_processGO:0002312 B cell activation involved in immune response IMP
 biological_processGO:0002323 natural killer cell activation involved in immune response IBA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006959 humoral immune response IBA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0009615 response to virus NAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030101 natural killer cell activation NAS
 biological_processGO:0030183 B cell differentiation IBA
 biological_processGO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
 biological_processGO:0035458 cellular response to interferon-beta IDA
 biological_processGO:0042100 B cell proliferation NAS
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045089 positive regulation of innate immune response NAS
 biological_processGO:0045343 regulation of MHC class I biosynthetic process NAS
 biological_processGO:0045581 negative regulation of T cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus TAS
 biological_processGO:0060337 type I interferon signaling pathway IDA
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 biological_processGO:0071360 cellular response to exogenous dsRNA TAS
 biological_processGO:2000552 negative regulation of T-helper 2 cell cytokine production IDA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005126 cytokine receptor binding IEA
 molecular_functionGO:0005132 type I interferon receptor binding NAS
 molecular_functionGO:0008811 chloramphenicol O-acetyltransferase activity IMP


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Interferon alpha/beta signaling
Regulation of IFNA signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / reaction / complex
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / reaction / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / reaction / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / reaction / complex
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction






 

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