ENSG00000170581


Homo sapiens

Features
Gene ID: ENSG00000170581
  
Biological name :STAT2
  
Synonyms : P52630 / signal transducer and activator of transcription 2 / STAT2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56341597
Gene end: 56360155
  
Corresponding Affymetrix probe sets: 205170_at (Human Genome U133 Plus 2.0 Array)   217199_s_at (Human Genome U133 Plus 2.0 Array)   225636_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450985
Ensembl peptide - ENSP00000315768
Ensembl peptide - ENSP00000387354
Ensembl peptide - ENSP00000450751
NCBI entrez gene - 6773     See in Manteia.
OMIM - 600556
RefSeq - XM_017019904
RefSeq - NM_198332
RefSeq - XM_005269111
RefSeq - XM_011538697
RefSeq - XM_011538698
RefSeq - XM_011538699
RefSeq - XM_011538700
RefSeq - NM_005419
RefSeq Peptide - NP_005410
RefSeq Peptide - NP_938146
swissprot - G3V319
swissprot - R9QE65
swissprot - B4DLC8
swissprot - P52630
Ensembl - ENSG00000170581
  
Related genetic diseases (OMIM): 616636 - Immunodeficiency 44, 616636

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stat2ENSDARG00000031647Danio rerio
 STAT2ENSGALG00000030661Gallus gallus
 Stat2ENSMUSG00000040033Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAT1 / P42224 / signal transducer and activator of transcription 1ENSG0000011541537
STAT3 / P40763 / signal transducer and activator of transcription 3ENSG0000016861035
STAT4 / Q14765 / signal transducer and activator of transcription 4ENSG0000013837835
P51692 / STAT5B / signal transducer and activator of transcription 5BENSG0000017375724
P42229 / STAT5A / signal transducer and activator of transcription 5AENSG0000012656123
STAT6 / P42226 / signal transducer and activator of transcription 6ENSG0000016688821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001217  Transcription factor STAT
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012345  STAT transcription factor, DNA-binding, N-terminal
 IPR013799  STAT transcription factor, protein interaction
 IPR013800  STAT transcription factor, all-alpha domain
 IPR013801  STAT transcription factor, DNA-binding
 IPR015988  STAT transcription factor, coiled coil
 IPR022756  Signal transducer and activation of transcription 2, C-terminal
 IPR035854  STAT2, SH2 domain
 IPR036535  STAT transcription factor, N-terminal domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060337 type I interferon signaling pathway IMP
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 biological_processGO:0090140 regulation of mitochondrial fission IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044389 ubiquitin-like protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-20 family signaling
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show

 HP:0001298 Encephalopathy 
Show

 HP:0003828 Variable expressivity 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / complex / reaction
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / complex / reaction
 ENSG00000142166 IFNAR1 / P17181 / interferon alpha and beta receptor subunit 1  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000213928 IRF9 / Q00978 / interferon regulatory factor 9  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / reaction / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr