ENSG00000142166


Homo sapiens

Features
Gene ID: ENSG00000142166
  
Biological name :IFNAR1
  
Synonyms : IFNAR1 / interferon alpha and beta receptor subunit 1 / P17181
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.11
Gene start: 33324477
Gene end: 33359862
  
Corresponding Affymetrix probe sets: 204191_at (Human Genome U133 Plus 2.0 Array)   225661_at (Human Genome U133 Plus 2.0 Array)   225669_at (Human Genome U133 Plus 2.0 Array)   236478_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000270139
Ensembl peptide - ENSP00000400161
NCBI entrez gene - 3454     See in Manteia.
OMIM - 107450
RefSeq - NM_000629
RefSeq - XM_005260964
RefSeq Peptide - NP_000620
swissprot - C9J114
swissprot - P17181
Ensembl - ENSG00000142166
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il10rbENSDARG00000078042Danio rerio
 IFNAR1ENSGALG00000030363Gallus gallus
 Ifnar1ENSMUSG00000022967Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL10RB / Q08334 / interleukin 10 receptor subunit betaENSG0000024364613
IFNGR2 / P38484 / interferon gamma receptor 2ENSG0000015912813


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR016669  Interferon alpha/beta receptor 1
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0035457 cellular response to interferon-alpha ISS
 biological_processGO:0060337 type I interferon signaling pathway IDA
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004904 interferon receptor activity IEA
 molecular_functionGO:0004905 type I interferon receptor activity IDA
 molecular_functionGO:0004920 interleukin-10 receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019962 type I interferon binding ISS


Pathways (from Reactome)
Pathway description
Interferon alpha/beta signaling
Regulation of IFNA signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170581 STAT2 / P52630 / signal transducer and activator of transcription 2  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000159110 IFNAR2 / P48551 / interferon alpha and beta receptor subunit 2  / complex / reaction
 ENSG00000171855 IFNB1 / P01574 / interferon beta 1  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / reaction / complex
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction






 

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