ENSG00000152495


Homo sapiens

Features
Gene ID: ENSG00000152495
  
Biological name :CAMK4
  
Synonyms : calcium/calmodulin dependent protein kinase IV / CAMK4 / Q16566
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q22.1
Gene start: 111223653
Gene end: 111494886
  
Corresponding Affymetrix probe sets: 210349_at (Human Genome U133 Plus 2.0 Array)   229029_at (Human Genome U133 Plus 2.0 Array)   241871_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422634
Ensembl peptide - ENSP00000421606
Ensembl peptide - ENSP00000423761
Ensembl peptide - ENSP00000426940
Ensembl peptide - ENSP00000424912
Ensembl peptide - ENSP00000282356
NCBI entrez gene - 814     See in Manteia.
OMIM - 114080
RefSeq - NM_001323374
RefSeq - NM_001323375
RefSeq - NM_001323376
RefSeq - NM_001323377
RefSeq - NM_001744
RefSeq Peptide - NP_001310305
RefSeq Peptide - NP_001735
RefSeq Peptide - NP_001310303
RefSeq Peptide - NP_001310304
RefSeq Peptide - NP_001310306
swissprot - D6REY7
swissprot - Q16566
swissprot - D6RE65
swissprot - D6RCD6
Ensembl - ENSG00000152495
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk4ENSDARG00000005372Danio rerio
 CAMK4ENSGALG00000000244Gallus gallus
 Camk4ENSMUSG00000038128Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAMK1 / Q14012 / calcium/calmodulin dependent protein kinase IENSG0000013407233
PNCK / Q6P2M8 / pregnancy up-regulated nonubiquitous CaM kinaseENSG0000013082232
CAMK1G / Q96NX5 / calcium/calmodulin dependent protein kinase IGENSG0000000811831
CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II deltaENSG0000014534931
CAMK1D / Q8IU85 / calcium/calmodulin dependent protein kinase IDENSG0000018304931
CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gammaENSG0000014866031
CAMKV / Q8NCB2 / CaM kinase like vesicle associatedENSG0000016407630
CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alphaENSG0000007080830
CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II betaENSG0000005840430
PSKH1 / P11801 / protein serine kinase H1ENSG0000015979227
PSKH2 / Q96QS6 / protein serine kinase H2ENSG0000014761326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007616 long-term memory IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0033081 regulation of T cell differentiation in thymus TAS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IMP
 biological_processGO:0045670 regulation of osteoclast differentiation TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046777 protein autophosphorylation IBA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IDA
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CaMK IV-mediated phosphorylation of CREB
Transcriptional activation of mitochondrial biogenesis
CREB phosphorylation through the activation of CaMKK
Activation of CaMK IV


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex / reaction
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction






 

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