ENSMUSG00000032356


Mus musculus

Features
Gene ID: ENSMUSG00000032356
  
Biological name :Rasgrf1
  
Synonyms : P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1
  
Possible biological names infered from orthology : Q13972
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.1
Gene start: 89909908
Gene end: 90026977
  
Corresponding Affymetrix probe sets: 10587699 (MoGene1.0st)   1422600_at (Mouse Genome 430 2.0 Array)   1424734_at (Mouse Genome 430 2.0 Array)   1435614_s_at (Mouse Genome 430 2.0 Array)   1459056_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140921
Ensembl peptide - ENSMUSP00000034909
Ensembl peptide - ENSMUSP00000034912
NCBI entrez gene - 19417     See in Manteia.
MGI - MGI:99694
RefSeq - XM_006510875
RefSeq - NM_001039655
RefSeq - NM_001357743
RefSeq - NM_011245
RefSeq Peptide - NP_035375
RefSeq Peptide - NP_001034744
RefSeq Peptide - NP_001344672
swissprot - A0A087WS68
swissprot - B2RS27
swissprot - P27671
swissprot - Q9QZR7
Ensembl - ENSMUSG00000032356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRF1ENSDARG00000073824Danio rerio
 RASGRF1ENSGALG00000008262Gallus gallus
 Q13972ENSG00000058335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2 / O14827* / Ras protein specific guanine nucleotide releasing factor 2*ENSMUSG0000002170859
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424113
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682113
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984413
Sos2 / Q02384 / Son of sevenless homolog 2 / Q07890* / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSMUSG0000003480112
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG0000004014610
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG000000264829
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413548
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388316
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265946


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030745  Ras-specific guanine nucleotide-releasing factor 1
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035020 regulation of Rac protein signal transduction IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0046578 regulation of Ras protein signal transduction IDA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction ISS
 biological_processGO:0048167 regulation of synaptic plasticity ISS
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:2000310 regulation of NMDA receptor activity IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030426 growth cone IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035254 glutamate receptor binding IPI


Pathways (from Reactome)
Pathway description
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Rasgrf1enu2H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1tm1Sva/Rasgrf1tm1Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1tm1Toc
Genetic Background: involves: 129/Sv

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Chattm1Jrs/Chattm1Jrs,Tg(CAG-cre/Esr1*)1Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Rasgrf1enu2H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0002802 abnormal discrimination learning "defects in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rasgrf1tm1Sva/Rasgrf1tm1Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
Show

Allelic Composition: Rasgrf1tm1Sva/Rasgrf1tm1Sva
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Rasgrf1enu2H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1enu1H/Rasgrf1+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6JOlaHsd

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Iglc1tm2Ust/Iglc1tm2Ust
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003787 abnormal imprinting "defect in the normal inactivation of specific loci during gametogenesis" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

Allelic Composition: Rasgrf1tm4.1Pds/Rasgrf1+,Tg(Zp3-cre)3Mrt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Rasgrf1tm3.1Pds/Rasgrf1+
Genetic Background: involves: FVB/N

Allelic Composition: Rasgrf1tm1Pds/Rasgrf1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrf1tm1Toc/Rasgrf1+
Genetic Background: involves: 129/Sv

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf11btm1Khs/Tnfrsf11btm1Khs
Genetic Background: B6.129P2-Tnfrsf11btm1Khs

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(CSF2)2Ygy/0,Tg(IL3)1Ygy/0,Tg(KITLG)3Ygy/0
Genetic Background: NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcer2atm1Max/Fcer2atm1Max
Genetic Background: involves: C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Mle/Engtm1Mle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / complex / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction / complex
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction / complex
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction / complex






 

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