ENSMUSG00000057897


Mus musculus

Features
Gene ID: ENSMUSG00000057897
  
Biological name :Camk2b
  
Synonyms : Calcium/calmodulin-dependent protein kinase type II subunit beta / Camk2b / P28652
  
Possible biological names infered from orthology : calcium/calmodulin dependent protein kinase II beta / Q13554
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 5969644
Gene end: 6066362
  
Corresponding Affymetrix probe sets: 10384064 (MoGene1.0st)   1448676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002817
Ensembl peptide - ENSMUSP00000019133
Ensembl peptide - ENSMUSP00000065101
Ensembl peptide - ENSMUSP00000105438
Ensembl peptide - ENSMUSP00000105440
Ensembl peptide - ENSMUSP00000087925
Ensembl peptide - ENSMUSP00000091046
Ensembl peptide - ENSMUSP00000099119
Ensembl peptide - ENSMUSP00000099120
Ensembl peptide - ENSMUSP00000105437
NCBI entrez gene - 12323     See in Manteia.
MGI - MGI:88257
RefSeq - XM_017314241
RefSeq - NM_001174053
RefSeq - NM_001174054
RefSeq - NM_007595
RefSeq - XM_006514465
RefSeq - XM_006514467
RefSeq - XM_006514469
RefSeq - XM_006514470
RefSeq - XM_006514475
RefSeq - XM_006514476
RefSeq - XM_006514477
RefSeq - XM_006514479
RefSeq - XM_017314237
RefSeq - XM_017314238
RefSeq - XM_017314239
RefSeq - XM_017314240
RefSeq - XM_006514464
RefSeq Peptide - NP_001167525
RefSeq Peptide - NP_031621
RefSeq Peptide - NP_001167524
swissprot - Q5SVI0
swissprot - Q5SVI1
swissprot - Q5SVI2
swissprot - Q5SVI3
swissprot - Q5SVI9
swissprot - Q5SVJ0
swissprot - Q5SVJ1
swissprot - Q68EG2
swissprot - P28652
Ensembl - ENSMUSG00000057897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 camk2b1ENSDARG00000011065Danio rerio
 camk2b2ENSDARG00000100089Danio rerio
 ENSGALG00000033061Gallus gallus
 CAMK2BENSG00000058404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*ENSMUSG0000002182081
Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*ENSMUSG0000005381979
Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*ENSMUSG0000002461775
Camk1g / Q91VB2 / Calcium/calmodulin-dependent protein kinase type 1G / Q96NX5* / calcium/calmodulin dependent protein kinase IG*ENSMUSG0000001617926
Camk4 / calcium/calmodulin-dependent protein kinase IV / Q16566*ENSMUSG0000003812826
Camk1 / Q91YS8 / calcium/calmodulin-dependent protein kinase I / Q14012*ENSMUSG0000003027225
Camk1d / Q8BW96 / calcium/calmodulin-dependent protein kinase ID / Q8IU85*ENSMUSG0000003914524
Pnck / Q9QYK9 / pregnancy upregulated non-ubiquitously expressed CaM kinase / Q6P2M8* / pregnancy up-regulated nonubiquitous CaM kinase*ENSMUSG0000000201224
Camkv / Q3UHL1 / CaM kinase-like vesicle-associated protein / Q8NCB2* / CaM kinase like vesicle associated*ENSMUSG0000003293622
Pskh1 / Q91YA2 / protein serine kinase H1 / P11801*ENSMUSG0000004831021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013543  Calcium/calmodulin-dependent protein kinase II, association-domain
 IPR017441  Protein kinase, ATP binding site
 IPR032710  NTF2-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0002030 inhibitory G-protein coupled receptor phosphorylation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0032222 regulation of synaptic transmission, cholinergic IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0046686 response to cadmium ion IDA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0060291 long-term synaptic potentiation ISO
 biological_processGO:0060466 activation of meiosis involved in egg activation IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis ISS
 biological_processGO:0090129 positive regulation of synapse maturation ISS
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 cellular_componentGO:0051233 spindle midzone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF/MAP kinase cascade
Interferon gamma signaling
Ion transport by P-type ATPases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Camk2btm1.1Ics/Camk2b+
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr
Genetic Background: involves: 129P2/OlaHsd

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

Allelic Composition: Camk2btm1.1Ics/Camk2b+
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Camk2btm1.1Ics/Camk2btm1.1Ics
Genetic Background: B6J.129S2(Cg)-Camk2btm1.1Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / complex / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / complex / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / complex / reaction
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / reaction
 ENSMUSG00000038387 Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*  / reaction
 ENSMUSG00000025958 Creb1 / Q01147 / Cyclic AMP-responsive element-binding protein 1 / P16220* / cAMP responsive element binding protein 1*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / complex / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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