ENSMUSG00000038387


Mus musculus

Features
Gene ID: ENSMUSG00000038387
  
Biological name :Rras
  
Synonyms : P10833 / related RAS viral (r-ras) oncogene / Rras
  
Possible biological names infered from orthology : P10301 / RAS related
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45017961
Gene end: 45021647
  
Corresponding Affymetrix probe sets: 10552824 (MoGene1.0st)   1418448_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147508
Ensembl peptide - ENSMUSP00000147980
Ensembl peptide - ENSMUSP00000042150
NCBI entrez gene - 20130     See in Manteia.
MGI - MGI:98179
RefSeq - NM_009101
RefSeq - XM_006540721
RefSeq Peptide - NP_033127
swissprot - A0A1B0GSL0
swissprot - P10833
swissprot - Q3U1N3
swissprot - A0A1B0GRG1
Ensembl - ENSMUSG00000038387
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrasENSDARG00000006553Danio rerio
 RRASENSG00000126458Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rras2 / P62071 / Ras-related protein R-Ras2 / P62070* / RAS related 2*ENSMUSG0000005572361
Nras / neuroblastoma ras oncogene / P01111* / NRAS proto-oncogene, GTPase*ENSMUSG0000002785247
Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*ENSMUSG0000002549947
Mras / O08989 / muscle and microspikes RAS / O14807* / muscle RAS oncogene homolog*ENSMUSG0000003247047
Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*ENSMUSG0000003026546
Ralb / Q9JIW9 / Ras-related protein Ral-B / P11234* / RAS like proto-oncogene B*ENSMUSG0000000445141
Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*ENSMUSG0000000885941
Rerg / Q8R367 / Ras-related and estrogen-regulated growth inhibitor / Q96A58* / RAS like estrogen regulated growth inhibitor*ENSMUSG0000003022232
Eras / Q7TN89 / GTPase ERas / Q7Z444* / ES cell expressed Ras*ENSMUSG0000003116032
Gem / P55041 / GTP-binding protein GEM / P55040* / GTP binding protein overexpressed in skeletal muscle*ENSMUSG0000002821431
Rrad / Ras-related associated with diabetes / P55042* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSMUSG0000003188029
Rem1 / O35929 / GTP-binding protein REM 1 / O75628* / RRAD and GEM like GTPase 1*ENSMUSG0000000035929
Q08AT1 / Rasl12 / Ras-like protein family member 12 / Q9NYN1* / RAS like family 12*ENSMUSG0000004169628
Rem2 / RRAD and GEM like GTPase 2 / Q8IYK8*ENSMUSG0000002217628
Q6IMB1 / Rasl11a / Ras-like protein family member 11A / Q6T310* / RAS like family 11 member A*ENSMUSG0000002964126
Rergl / RERG/RAS-like / Q9H628* / RERG like*ENSMUSG0000009216426
Q922H7 / Rasl11b / Ras-like protein family member 11B / Q9BPW5* / RAS like family 11 member B*ENSMUSG0000004990723


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002521 leukocyte differentiation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030336 negative regulation of cell migration IGI
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051896 regulation of protein kinase B signaling IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Sema4D mediated inhibition of cell attachment and migration
CREB phosphorylation through the activation of Ras


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0006135 arterial stenosis "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catf/Catf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000054855 Rnd1 / Q8BLR7 / Rho-related GTP-binding protein Rho6 / Q92730* / Rho family GTPase 1*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / reaction






 

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