MP:0000026 | abnormal inner ear morphology | "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi
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MP:0000534 | abnormal ureter morphology | "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0000819 | abnormal olfactory bulb morphology | "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0000826 | abnormal third ventricle morphology | "malformation or absence of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0000841 | abnormal hindbrain morphology | "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Allelic Composition: RalaGt(DD1113)Wtsi/RalaGt(DD1113)Wtsi Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
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MP:0001015 | small superior cervical ganglion | "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0001303 | abnormal lens morphology | "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi
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MP:0001917 | intraventricular hemorrhage | "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi
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MP:0003447 | reduced tumor growth/size | "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383] |
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Allelic Composition: Ralatm1.1Cjm/Rala+,Ralbtm1.1Cjm/Ralbtm1.1Cjm Genetic Background: involves: C57BL/6 * C57BL/6J
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MP:0003686 | abnormal eye muscle morphology | "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0003826 | abnormal Mullerian duct morphology | "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0003827 | abnormal Wolffian duct morphology | "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Allelic Composition: Ralatm1.1Cjm/Rala+,Ralbtm1.1Cjm/Ralbtm1.1Cjm Genetic Background: involves: C57BL/6 * C57BL/6J
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MP:0004160 | retroesophageal right subclavian artery | "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0004268 | abnormal optic stalk morphology | "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0005262 | coloboma | "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0005296 | abnormal humerus morphology | "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0006054 | spinal hemorrhage | "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0009493 | abnormal cystic duct morphology | "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0009688 | abnormal spinal cord central canal morphology | "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: RalaGt(DD1113)Wtsi/RalaGt(DD1113)Wtsi Genetic Background: involves: 129P2/OlaHsd
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MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Ralatm1.1Cjm/Rala+,Ralbtm1.1Cjm/Ralbtm1.1Cjm Genetic Background: involves: C57BL/6 * C57BL/6J
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MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
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MP:0011110 | partial preweaning lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0011513 | abnormal vertebral artery morphology | "any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr,Smug1tm1a(EUCOMM)Hmgu/Smug1tm1a(EUCOMM)Hmgu,Ungtm1Tld/Ungtm1Tld Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
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MP:0013840 | absent segment of posterior cerebral artery | "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013873 | abnormal ductus venosus morphology | "any structural anomaly of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013877 | abnormal ductus venosus valve morphology | "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013968 | multiple persisting craniopharyngeal ducts | |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013969 | reduced sympathetic cervical ganglion size | |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013971 | blood in lymph vessels | |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0013986 | abnormal vitelline vein topology | "abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0014000 | anastomosis between internal carotid artery and basilar artery | |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0014001 | abnormal vertebral artery topology | "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith] |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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MP:0014019 | embryo cyst | |
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Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi
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