ENSMUSG00000020524


Mus musculus

Features
Gene ID: ENSMUSG00000020524
  
Biological name :Gria1
  
Synonyms : Glutamate receptor 1 / Gria1 / P23818
  
Possible biological names infered from orthology : glutamate ionotropic receptor AMPA type subunit 1 / P42261
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.3
Gene start: 57011387
Gene end: 57330244
  
Corresponding Affymetrix probe sets: 10376245 (MoGene1.0st)   1435239_at (Mouse Genome 430 2.0 Array)   1448972_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044494
Ensembl peptide - ENSMUSP00000091731
Ensembl peptide - ENSMUSP00000117746
Ensembl peptide - ENSMUSP00000133439
NCBI entrez gene - 14799     See in Manteia.
MGI - MGI:95808
RefSeq - XM_017314275
RefSeq - NM_001113325
RefSeq - NM_001252403
RefSeq - NM_008165
RefSeq - XM_006532234
RefSeq Peptide - NP_001239332
RefSeq Peptide - NP_032191
RefSeq Peptide - NP_001106796
swissprot - P23818
swissprot - Q7TNB5
swissprot - F6YNQ1
Ensembl - ENSMUSG00000020524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gria1aENSDARG00000021352Danio rerio
 gria1bENSDARG00000032714Danio rerio
 GRIA1ENSGALG00000004083Gallus gallus
 GRIA1ENSG00000155511Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589267
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198666
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398166
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607338
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293537
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198537
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201735
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337833
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107826
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142424
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073422
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900321
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020921
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277121
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695920
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574519
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957917


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0060292 long term synaptic depression IGI
 biological_processGO:0099566 regulation of postsynaptic cytosolic calcium ion concentration IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IDA
 cellular_componentGO:0009986 cell surface IMP
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IDA
 cellular_componentGO:0032590 dendrite membrane IMP
 cellular_componentGO:0032591 dendritic spine membrane IEA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044308 axonal spine IDA
 cellular_componentGO:0044309 neuron spine IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0098794 postsynapse IDA
 cellular_componentGO:0098839 postsynaptic density membrane IDA
 cellular_componentGO:0099061 integral component of postsynaptic density membrane IC
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004971 AMPA glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IMP
 molecular_functionGO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Activation of AMPA receptors
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Gria1tm1Lex/Gria1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gria1tm4Rlh/Gria1tm4Rlh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Gria1tm5Rlh/Gria1tm5Rlh
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gria1tm5Rlh/Gria1tm5Rlh
Genetic Background: involves: 129 * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli3Xt-J/Gli3+
Genetic Background: involves: C3H/HeJ

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgaltm1.1Mshi/Itgaltm1.1Mshi
Genetic Background: involves: C57BL/6

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pofut1tm1Pst/Pofut1cax
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gria1tm1Erk/Gria1tm1Erk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cnih2tm1.1Ran/Cnih2tm1.1Ran,Cnih3tm1.1Ran/Cnih3tm1.1Ran
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gria1tm1Lex/Gria1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006352 decreased glycosylated hemoglobin level "lower than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
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Allelic Composition: Gria1tm1Lex/Gria1tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dstncorn1/Dstncorn1,Cxcr2tm1Mwm/Cxcr2tm1Mwm
Genetic Background: involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbtm1.1Yko/Ednrbtm1.1Yko
Genetic Background: involves: 129P2/OlaHsd * Bkl:BKW * C57BL/6 * SJL

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca2tm2Hst/Brca2tm2Hst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009713 enhanced conditioned place preference behavior "increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pofut1tm1Pst/Pofut1cax
Genetic Background: involves: 129/Sv * C57BL/6J * SJL/J

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F5tm2Dgi/F5tm2Dgi
Genetic Background: B6.129S2-F5tm2Dgi

Allelic Composition: Gria1tm2Rsp/Gria1tm2Rsp,Tg(Pvalb-cre)1Mony/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gria1tm1Rsp/Gria1tm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction
 ENSMUSG00000068206 Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*  / reaction
 ENSMUSG00000024873 2 / Cnih2 / O35089 / Q6PI25* / cornichon family AMPA receptor auxiliary protein 2*  / complex / reaction
 ENSMUSG00000026514 3 / Cnih3 / Q6ZWS4 / Q8TBE1* / cornichon family AMPA receptor auxiliary protein 3*  / complex / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction
 ENSMUSG00000034813 Grip1 / Q925T6 / Glutamate receptor-interacting protein 1 / Q9Y3R0*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction / complex
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction






 

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