ENSMUSG00000034813


Mus musculus

Features
Gene ID: ENSMUSG00000034813
  
Biological name :Grip1
  
Synonyms : Glutamate receptor-interacting protein 1 / Grip1 / Q925T6
  
Possible biological names infered from orthology : Q9Y3R0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D2
Gene start: 119453830
Gene end: 120087261
  
Corresponding Affymetrix probe sets: 10366597 (MoGene1.0st)   1421350_a_at (Mouse Genome 430 2.0 Array)   1435951_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121670
Ensembl peptide - ENSMUSP00000118397
Ensembl peptide - ENSMUSP00000122323
Ensembl peptide - ENSMUSP00000123288
Ensembl peptide - ENSMUSP00000123234
Ensembl peptide - ENSMUSP00000122349
Ensembl peptide - ENSMUSP00000042436
Ensembl peptide - ENSMUSP00000077033
Ensembl peptide - ENSMUSP00000080016
Ensembl peptide - ENSMUSP00000100896
Ensembl peptide - ENSMUSP00000100897
Ensembl peptide - ENSMUSP00000115478
Ensembl peptide - ENSMUSP00000118073
NCBI entrez gene - 74053     See in Manteia.
MGI - MGI:1921303
RefSeq - XM_017314126
RefSeq - NM_001277292
RefSeq - NM_001277293
RefSeq - NM_001277294
RefSeq - NM_001277295
RefSeq - NM_028736
RefSeq - NM_130891
RefSeq - NM_133442
RefSeq - XM_006514231
RefSeq - XM_006514232
RefSeq - XM_006514233
RefSeq - XM_006514234
RefSeq - XM_006514235
RefSeq - XM_006514236
RefSeq - XM_006514237
RefSeq - XM_006514238
RefSeq - XM_006514239
RefSeq - XM_006514242
RefSeq Peptide - NP_001264224
RefSeq Peptide - NP_083012
RefSeq Peptide - NP_570961
RefSeq Peptide - NP_597699
RefSeq Peptide - NP_001264221
RefSeq Peptide - NP_001264222
RefSeq Peptide - NP_001264223
swissprot - D3YWY4
swissprot - D3Z6T4
swissprot - Q6GQT7
swissprot - Q6X4T6
swissprot - D3Z6R6
swissprot - D3Z066
swissprot - H7BX09
swissprot - H7BX90
swissprot - D3YZL8
swissprot - Q925T6
Ensembl - ENSMUSG00000034813
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grip1ENSDARG00000015053Danio rerio
 GRIP1ENSGALG00000009895Gallus gallus
 GRIP1ENSG00000155974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grip2 / glutamate receptor interacting protein 2ENSMUSG0000003009857


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR030026  Glutamate receptor-interacting protein 1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0016358 dendrite development IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0055037 recycling endosome IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding ISO


Pathways (from Reactome)
Pathway description
Trafficking of GluR2-containing AMPA receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha
Genetic Background: B6.129-Grip1tm1Rha

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha
Genetic Background: B6.129-Grip1tm1Rha

 MP:0000549 absent limbs "missing extremities" [J:51966, J:50768]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcb1tm1Mya/Smarcb1tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcb1tm1Mya/Smarcb1tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0000576 clubbed feet "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha
Genetic Background: B6.129-Grip1tm1Rha

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1(cre/ERT)Mrc/Bmi1+,Ctnnb1tm1Mmt/Ctnnb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0003604 single kidney 
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0005242 cryptophthalmos "congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83745]
Show

Allelic Composition: Grip1tm1Rha/Grip1tm1Rha,Grip2tm1Rha/Grip2tm1Rha
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0006203 eye hemorrhage "bleeding into the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0008854 bleb "presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grip1eb/Grip1eb
Genetic Background: involves: hairless stock

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Smarcb1tm1Mya/Smarcb1tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011961 abnormal cornea thickness "increased or decreased width of the cornea in the center plane" [MGI:csmith]
Show

Allelic Composition: Raxtm1.1Lwd/Raxtm1.1Lwd,Tg(rx3-icre)1Mjam/0
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction
 ENSMUSG00000068206 Pick1 / protein interacting with C kinase 1 / Q9NRD5* / protein interacting with PRKCA 1*  / reaction
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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