ENSMUSG00000059003


Mus musculus

Features
Gene ID: ENSMUSG00000059003
  
Biological name :Grin2a
  
Synonyms : Glutamate receptor ionotropic, NMDA 2A / Grin2a / P35436
  
Possible biological names infered from orthology : glutamate ionotropic receptor NMDA type subunit 2A / Q12879
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 9567898
Gene end: 9995560
  
Corresponding Affymetrix probe sets: 10437629 (MoGene1.0st)   1421616_at (Mouse Genome 430 2.0 Array)   1434638_at (Mouse Genome 430 2.0 Array)   1447385_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032331
Ensembl peptide - ENSMUSP00000111501
Ensembl peptide - ENSMUSP00000142900
NCBI entrez gene - 14811     See in Manteia.
MGI - MGI:95820
RefSeq - XM_006521795
RefSeq - NM_008170
RefSeq - XM_006521794
RefSeq Peptide - NP_032196
swissprot - P35436
Ensembl - ENSMUSG00000059003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grin2aaENSDARG00000034493Danio rerio
 grin2abENSDARG00000070543Danio rerio
 GRIN2AENSGALG00000007278Gallus gallus
 GRIN2AENSG00000183454Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020953
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073439
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277137
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957917
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574516
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695916
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198513
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337813
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607313
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293513
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201713
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589213
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052413
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142413
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198612
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107812
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR018884  Glutamate [NMDA] receptor, epsilon subunit, C-terminal
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001964 startle response IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0007626 locomotory behavior TAS
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030431 sleep IMP
 biological_processGO:0033058 directional locomotion IGI
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0040011 locomotion IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IGI
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0042417 dopamine metabolic process IMP
 biological_processGO:0042428 serotonin metabolic process IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0045471 response to ethanol ISO
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0051930 regulation of sensory perception of pain IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0060291 long-term synaptic potentiation IGI
 biological_processGO:0097553 calcium ion transmembrane import into cytosol ISO
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1903539 protein localization to postsynaptic membrane IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0009986 cell surface IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IMP
 cellular_componentGO:0043197 dendritic spine ISO
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0045211 postsynaptic membrane IDA
 cellular_componentGO:0098839 postsynaptic density membrane IDA
 cellular_componentGO:0099061 integral component of postsynaptic density membrane IDA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0004972 NMDA glutamate receptor activity ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IMP
 molecular_functionGO:0005262 calcium channel activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0022849 glutamate-gated calcium ion channel activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Grin2atm1.1Nhk/Grin2atm1.1Nhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Grin2atm1.1Jpleo/Grin2atm1.1Jpleo
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001401 jumpy "marked by fitful, jerky movements" [J:22295]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Grin2atm1Rsp/Grin2atm1Rsp,Grin2ctm1Rsp/Grin2ctm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grin2atm1.1Nhk/Grin2atm1.1Nhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Grin2atm1.1Jpleo/Grin2atm1.1Jpleo
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin2atm1Rsp/Grin2atm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grid2tm1Mim/Grid2tm1Mim
Genetic Background: B6.Cg-Grid2tm1Mim

 MP:0001500 reduced kindling behavior "fewer epileptic episodes induced by daily sub threshold electrical brain stimulation" [J:45446]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Grin2atm1Nak/Grin2atm1Nak,Grin2ctm1Nak/Grin2ctm1Nak
Genetic Background: involves: 129S/SvEv

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin1tm2Blt/Grin1tm2Blt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Grin2atm1.1Tnkw/Grin2atm1.1Tnkw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

Allelic Composition: Grin2atm1Nak/Grin2atm1Nak,Grin2ctm1Nak/Grin2ctm1Nak
Genetic Background: involves: 129S/SvEv

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

Allelic Composition: Grin2atm1Nak/Grin2atm1Nak,Grin2ctm1Nak/Grin2ctm1Nak
Genetic Background: involves: 129S/SvEv

Allelic Composition: Grin2atm1.1Tnkw/Grin2atm1.1Tnkw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Grin2atm1.1Tnkw/Grin2atm1.1Tnkw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm2(CUX1)Anep/Hprt+
Genetic Background: FVB.129P2-Hprttm2(CUX1)Anep

Allelic Composition: Grin2atm1Nak/Grin2atm1Nak,Grin2ctm1Nak/Grin2ctm1Nak
Genetic Background: involves: 129S/SvEv

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2atm1.1Jpleo/Grin2atm1.1Jpleo
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2atm1.1Ppao/Grin2atm1.1Ppao
Genetic Background: involves: 129 * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2atm1Rsp/Grin2atm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grin2atm1Rsp/Grin2atm1Rsp,Grin2ctm1Rsp/Grin2ctm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Grin2atm1.1Nhk/Grin2atm1.1Nhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / complex / reaction
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction / complex
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / complex / reaction
 ENSMUSG00000025892 Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / complex
 ENSMUSG00000020524 Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction / complex
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / complex
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / complex
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction / complex
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / complex
 ENSMUSG00000040490 Lrfn2 / Q80TG9 / Leucine-rich repeat and fibronectin type-III domain-containing protein 2 / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / complex / reaction
 ENSMUSG00000030600 Lrfn1 / Q2WF71 / Leucine-rich repeat and fibronectin type III domain-containing protein 1 / Q9P244* / leucine rich repeat and fibronectin type III domain containing 1*  / reaction / complex
 ENSMUSG00000001986 Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*  / reaction






 

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