ENSDARG00000070543


Danio rerio

Features
Gene ID: ENSDARG00000070543
  
Biological name :grin2ab
  
Synonyms : glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b / grin2ab
  
Possible biological names infered from orthology : glutamate ionotropic receptor NMDA type subunit 2A / Glutamate receptor ionotropic, NMDA 2A / GRIN2A / P35436 / Q12879
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 8763429
Gene end: 8928841
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000094428
Ensembl peptide - ENSDARP00000120094
NCBI entrez gene - 570493     See in Manteia.
swissprot - F1QDE5
ZFIN ID - ZDB-GENE-070424-223
Ensembl - ENSDARG00000070543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRIN2AENSGALG00000007278Gallus gallus
 GRIN2AENSG00000183454Homo sapiens
 Grin2aENSMUSG00000059003Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grin2aa / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, a / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*ENSDARG0000003449363
grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...ENSDARG0000003037648
LO018552.1 / GRIN2B* / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSDARG0000007934843
grin2ca / glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*ENSDARG0000007814938
grin2cb / glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*ENSDARG0000007756037
grin2da / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*ENSDARG0000008620734
grin2db / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, b / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*ENSDARG0000007062030
grin1b / glutamate receptor, ionotropic, N-methyl D-aspartate 1b / GRIN1* / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 * / glutamate ionotropic receptor NMDA type subunit 1*ENSDARG0000002572816
grin3ba / glutamate receptor, ionotropic, N-methyl-D-aspartate 3Ba / Q91ZU9* / GRIN3B* / O60391* / Glutamate receptor ionotropic, NMDA 3B * / glutamate ionotropic receptor NMDA type subunit 3B*ENSDARG0000000536416
grin3bb / glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb / Q91ZU9* / GRIN3B* / O60391* / Glutamate receptor ionotropic, NMDA 3B * / glutamate ionotropic receptor NMDA type subunit 3B*ENSDARG0000009866715
grin3a / glutamate receptor, ionotropic, N-methyl-D-aspartate 3A / Q8TCU5* / glutamate ionotropic receptor NMDA type subunit 3A*ENSDARG0000007580215
grin1a / glutamate receptor, ionotropic, N-methyl D-aspartate 1a / GRIN1* / P35438* / Q05586* / Glutamate receptor ionotropic, NMDA 1 * / glutamate ionotropic receptor NMDA type subunit 1*ENSDARG0000002782815
grik5 / glutamate receptor, ionotropic, kainate 5 / Q16478* / Q61626* / glutamate ionotropic receptor kainate type subunit 5*ENSDARG0000010144914
gria1a / glutamate receptor, ionotropic, AMPA 1a / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*ENSDARG0000002135213
grid2 / glutamate receptor, ionotropic, delta 2 / O43424* / Q61625* / glutamate ionotropic receptor delta type subunit 2*ENSDARG0000005530213
GRIK2 / glutamate ionotropic receptor kainate type subunit 2 / P39087* / Q13002* / Glutamate receptor ionotropic, kainate 2 *ENSDARG0000011377113
gria4b / glutamate receptor, ionotropic, AMPA 4bENSDARG0000005936813
grik4 / glutamate receptor, ionotropic, kainate 4 / Q16099* / Q8BMF5* / glutamate ionotropic receptor kainate type subunit 4*ENSDARG0000002675313
gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...ENSDARG0000003749813
GRIK3 / glutamate ionotropic receptor kainate type subunit 3 / Q13003*ENSDARG0000007771513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR018884  Glutamate [NMDA] receptor, epsilon subunit, C-terminal
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037498 gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032737 gria3a / glutamate receptor, ionotropic, AMPA 3a / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032714 gria1b / glutamate receptor, ionotropic, AMPA 1b / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / complex / reaction
 ENSDARG00000002816 A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...  / reaction / complex
 ENSDARG00000075054 rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*  / reaction / complex
 ENSDARG00000073824 RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*  / reaction / complex
 ENSDARG00000086207 grin2da / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*  / complex
 ENSDARG00000106248 BX548062.1 / LRFN2* / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2*  / complex / reaction
 ENSDARG00000077489 lrfn2b / leucine rich repeat and fibronectin type III domain containing 2b / LRFN2* / Q80TG9* / Q9ULH4* / leucine rich repeat and fibronectin type III domain containing 2* / Leucine-rich re...  / reaction / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / complex
 ENSDARG00000078149 grin2ca / glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / complex
 ENSDARG00000070543 grin2ab / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*  / complex
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / reaction / complex
 ENSDARG00000077560 grin2cb / glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / complex






 

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