ENSDARG00000075054


Danio rerio

Features
Gene ID: ENSDARG00000075054
  
Biological name :rasgrf2a
  
Synonyms : rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a
  
Possible biological names infered from orthology : O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / ras-specific guanine nucleotide-releasing factor 2
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 3049636
Gene end: 3106762
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000146913
Ensembl peptide - ENSDARP00000076233
Ensembl peptide - ENSDARP00000154000
Ensembl peptide - ENSDARP00000154655
NCBI entrez gene - 558859     See in Manteia.
swissprot - E7FBN7
ZFIN ID - ZDB-GENE-111128-1
Ensembl - ENSDARG00000075054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRF2ENSGALG00000015598Gallus gallus
 O14827ENSG00000113319Homo sapiens
 Rasgrf2ENSMUSG00000021708Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...ENSDARG0000000281686
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382465
rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a / Q13905* / RAPGEF1* / Rap guanine nucleotide exchange factor 1* / Rap guanine nucleotide exchange factor (GEF) 1*ENSDARG0000004359312
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597112
sos2 / son of sevenless homolog 2 (Drosophila) / Q02384* / Q07890* / Son of sevenless homolog 2 * / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSDARG0000006050612
si:ch211-251j10.3 / RGL4* / RGL2* / Q61193* / Q8IZJ4* / RALGDS* / O15211* / Q03385* / Q12967* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissoc...ENSDARG0000004240910
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG0000007121310
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG0000000598910
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG000000077278
sos1 / son of sevenless homolog 1 (Drosophila) / Q07889* / Q62245* / Son of sevenless homolog 1 * / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSDARG000001005037
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG000000265197
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG000000683707


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030744  Ras-specific guanine nucleotide-releasing factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000043010 Q6DEH3 / camk2d1 / calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1 / CAMK2D* / Q13557* / Q6PHZ2* / calcium/calmodulin dependent protein kinase II delta* / Mus musculus c...  / complex / reaction
 ENSDARG00000100825 calm2a / calm2b / calm3a / Q6PI52 / calmodulin 2a (phosphorylase kinase, delta)  / reaction / complex
 ENSDARG00000086207 grin2da / glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a / Q03391* / GRIN2D* / O15399* / Glutamate receptor ionotropic, NMDA 2D * / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction / complex
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / reaction / complex
 ENSDARG00000077560 grin2cb / glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSDARG00000002816 A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...  / complex
 ENSDARG00000078149 grin2ca / glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca / Q14957* / GRIN2C* / Q01098* / Glutamate receptor ionotropic, NMDA 2C * / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction / complex
 ENSDARG00000075054 rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*  / complex
 ENSDARG00000005651 hrasb / -Ha-ras Harvey rat sarcoma viral oncogene homolog b / HRAS* / P01112* / Q61411* / HRas proto-oncogene, GTPase* / GTPase HRas GTPase HRas, N-terminally processed*  / reaction
 ENSDARG00000070543 grin2ab / glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b / Q12879* / GRIN2A* / P35436* / Glutamate receptor ionotropic, NMDA 2A * / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction / complex
 ENSDARG00000073824 RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*  / complex






 

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