ENSDARG00000060506


Danio rerio

Features
Gene ID: ENSDARG00000060506
  
Biological name :sos2
  
Synonyms : son of sevenless homolog 2 (Drosophila) / sos2
  
Possible biological names infered from orthology : Q02384 / Q07890 / Son of sevenless homolog 2 / SOS Ras/Rho guanine nucleotide exchange factor 2
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 36638955
Gene end: 36663358
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000079754
NCBI entrez gene - 561670     See in Manteia.
swissprot - F1R019
ZFIN ID - ZDB-GENE-090319-5
Ensembl - ENSDARG00000060506
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOS2ENSGALG00000012273Gallus gallus
 SOS2ENSG00000100485Homo sapiens
 Sos2ENSMUSG00000034801Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sos1 / son of sevenless homolog 1 (Drosophila) / Q07889* / Q62245* / Son of sevenless homolog 1 * / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSDARG0000010050334
rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a / Q13905* / RAPGEF1* / Rap guanine nucleotide exchange factor 1* / Rap guanine nucleotide exchange factor (GEF) 1*ENSDARG0000004359316
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597116
A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...ENSDARG0000000281612
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382412
rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*ENSDARG0000007505411
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG000000059899
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG000000712139
si:ch211-251j10.3 / RGL4* / RGL2* / Q61193* / Q8IZJ4* / RALGDS* / O15211* / Q03385* / Q12967* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissoc...ENSDARG000000424099
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG000000077278
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG000000265197
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG000000683706


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Interleukin-15 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros decreased functionality , abnormal
pronephros spatial pattern , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001338 intestine intestine edematous , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus spatial pattern , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule morphology , abnormal
pronephric proximal convoluted tubule decreased size , abnormal
pronephric proximal convoluted tubule spatial pattern , abnormal
pronephric proximal convoluted tubule increased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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