ENSDARG00000100503


Danio rerio

Features
Gene ID: ENSDARG00000100503
  
Biological name :sos1
  
Synonyms : son of sevenless homolog 1 (Drosophila) / sos1
  
Possible biological names infered from orthology : Q07889 / Q62245 / Son of sevenless homolog 1 / SOS Ras/Rac guanine nucleotide exchange factor 1
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 45436703
Gene end: 45465268
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000134064
Ensembl peptide - ENSDARP00000142552
Ensembl peptide - ENSDARP00000142529
Ensembl peptide - ENSDARP00000142501
Ensembl peptide - ENSDARP00000142330
Ensembl peptide - ENSDARP00000142293
NCBI entrez gene - 556286     See in Manteia.
swissprot - A2RRV5
swissprot - A0A140LH22
swissprot - A0A140LGZ9
swissprot - A0A140LGX2
swissprot - A0A140LGF1
swissprot - A0A140LGB4
ZFIN ID - ZDB-GENE-070209-128
Ensembl - ENSDARG00000100503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SOS1ENSGALG00000039450Gallus gallus
 SOS1ENSG00000115904Homo sapiens
 Sos1ENSMUSG00000024241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sos2 / son of sevenless homolog 2 (Drosophila) / Q02384* / Q07890* / Son of sevenless homolog 2 * / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSDARG0000006050664
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG0000000598916
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG0000007121314
rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a / Q13905* / RAPGEF1* / Rap guanine nucleotide exchange factor 1* / Rap guanine nucleotide exchange factor (GEF) 1*ENSDARG0000004359314
si:ch211-251j10.3 / RGL4* / RGL2* / Q61193* / Q8IZJ4* / RALGDS* / O15211* / Q03385* / Q12967* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissoc...ENSDARG0000004240914
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597114
A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...ENSDARG0000000281613
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382413
rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*ENSDARG0000007505413
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG0000006837012
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG0000002651912
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG0000000772711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
SOS-mediated signalling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
Rho GTPase cycle
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
Activated NTRK2 signals through FRS2 and FRS3
Interleukin receptor SHC signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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