ENSMUSG00000021708


Mus musculus

Features
Gene ID: ENSMUSG00000021708
  
Biological name :Rasgrf2
  
Synonyms : Rasgrf2 / ras-specific guanine nucleotide-releasing factor 2
  
Possible biological names infered from orthology : O14827 / Ras protein specific guanine nucleotide releasing factor 2
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 91880400
Gene end: 92131656
  
Corresponding Affymetrix probe sets: 10410995 (MoGene1.0st)   1421621_at (Mouse Genome 430 2.0 Array)   1440849_at (Mouse Genome 430 2.0 Array)   1440918_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115562
Ensembl peptide - ENSMUSP00000149731
Ensembl peptide - ENSMUSP00000116892
Ensembl peptide - ENSMUSP00000116203
Ensembl peptide - ENSMUSP00000096930
Ensembl peptide - ENSMUSP00000115401
NCBI entrez gene - 19418     See in Manteia.
MGI - MGI:109137
RefSeq - NM_009027
RefSeq Peptide - NP_033053
swissprot - F6TCD3
swissprot - D3Z6K8
swissprot - F7B9R2
swissprot - F6TYF8
swissprot - D3Z685
swissprot - A0A1L1SS23
Ensembl - ENSMUSG00000021708
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A2CEA7ENSDARG00000002816Danio rerio
 rasgrf2aENSDARG00000075054Danio rerio
 RASGRF2ENSGALG00000015598Gallus gallus
 O14827ENSG00000113319Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*ENSMUSG0000003235663
Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSMUSG0000002424113
Sos2 / Q02384 / Son of sevenless homolog 2 / Q07890* / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSMUSG0000003480113
Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*ENSMUSG0000002682113
Rapgef1 / Rap guanine nucleotide exchange factor (GEF) 1 / Q13905* / Rap guanine nucleotide exchange factor 1*ENSMUSG0000003984413
Rgl3 / Q3UYI5 / Ral guanine nucleotide dissociation stimulator-like 3 / Q3MIN7*ENSMUSG0000004014611
Rgl1 / Q60695 / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA. / Q9NZL6* / ral guanine nucleotide dissociation stimulator like 1*ENSMUSG0000002648210
Rgl2 / Q61193 / Ral guanine nucleotide dissociation stimulator-like 2 / O15211*ENSMUSG000000413549
A2AR50 / Ralgps1 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q5JS13* / Ral GEF with PH domain and SH3 binding motif 1*ENSMUSG000000388317
Q9ERD6 / Ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27*ENSMUSG000000265947


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000219  Dbl homology (DH) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001849  Pleckstrin homology domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011993  PH-like domain superfamily
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR030744  Ras-specific guanine nucleotide-releasing factor 2
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpv5Hcalc1/Trpv5Hcalc1
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11unm/Card11unm
Genetic Background: C57BL/6JSfdAnu-Card11unm/Anu

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S2/SvPas * C57BL/10 * C57BR/cd

Allelic Composition: Rasgrf2tm1Esn/Rasgrf2tm1Esn,Vav1tm1Tyb/Vav1tm1Tyb
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/10 * C57BR/cd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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