ENSG00000160271


Homo sapiens

Features
Gene ID: ENSG00000160271
  
Biological name :RALGDS
  
Synonyms : Q12967 / RALGDS / ral guanine nucleotide dissociation stimulator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.2
Gene start: 133097720
Gene end: 133149334
  
Corresponding Affymetrix probe sets: 209050_s_at (Human Genome U133 Plus 2.0 Array)   209051_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495963
Ensembl peptide - ENSP00000391814
Ensembl peptide - ENSP00000494152
Ensembl peptide - ENSP00000361117
Ensembl peptide - ENSP00000361120
Ensembl peptide - ENSP00000361132
Ensembl peptide - ENSP00000376864
Ensembl peptide - ENSP00000376867
NCBI entrez gene - 5900     See in Manteia.
OMIM - 601619
RefSeq - NM_001271774
RefSeq - NM_001042368
RefSeq - NM_001271775
RefSeq - NM_001271776
RefSeq - NM_006266
RefSeq Peptide - NP_001035827
RefSeq Peptide - NP_001258703
RefSeq Peptide - NP_001258704
RefSeq Peptide - NP_001258705
RefSeq Peptide - NP_006257
swissprot - Q12967
swissprot - Q5T7U6
Ensembl - ENSG00000160271
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-251j10.3ENSDARG00000042409Danio rerio
 ENSGALG00000003412Gallus gallus
 Q03385ENSMUSG00000026821Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL162417.1ENSG0000028524595
RGL1 / Q9NZL6 / ral guanine nucleotide dissociation stimulator like 1ENSG0000014334441
RGL2 / O15211 / ral guanine nucleotide dissociation stimulator like 2ENSG0000023744132
RGL3 / Q3MIN7 / ral guanine nucleotide dissociation stimulator like 3ENSG0000020551732
RGL4 / Q8IZJ4 / ral guanine nucleotide dissociation stimulator like 4ENSG0000015949621
O14827 / RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2ENSG0000011331919
Q13972 / RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1ENSG0000005833518
SOS2 / Q07890 / SOS Ras/Rho guanine nucleotide exchange factor 2ENSG0000010048518
SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1ENSG0000011590417
Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1ENSG0000010726315
Q86X27 / RALGPS2 / Ral GEF with PH domain and SH3 binding motif 2ENSG0000011619114
Q5JS13 / RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1ENSG0000013682814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR015758  Ral guanine nucleotide dissociation stimulator
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005903 brush border IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030695 GTPase regulator activity NAS


Pathways (from Reactome)
Pathway description
p38MAPK events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / complex / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000144118 RALB / P11234 / RAS like proto-oncogene B  / reaction
 ENSG00000006451 RALA / P11233 / RAS like proto-oncogene A  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr