ENSG00000144118


Homo sapiens

Features
Gene ID: ENSG00000144118
  
Biological name :RALB
  
Synonyms : P11234 / RALB / RAS like proto-oncogene B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.2
Gene start: 120240064
Gene end: 120294713
  
Corresponding Affymetrix probe sets: 202100_at (Human Genome U133 Plus 2.0 Array)   202101_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393782
Ensembl peptide - ENSP00000398162
Ensembl peptide - ENSP00000487037
Ensembl peptide - ENSP00000414224
Ensembl peptide - ENSP00000407062
Ensembl peptide - ENSP00000402866
Ensembl peptide - ENSP00000272519
NCBI entrez gene - 5899     See in Manteia.
OMIM - 179551
RefSeq - XM_017004622
RefSeq - XM_005263724
RefSeq - XM_005263727
RefSeq - XM_005263728
RefSeq - XM_005263729
RefSeq - XM_011511573
RefSeq - XM_011511574
RefSeq - XM_017004621
RefSeq - NM_002881
RefSeq Peptide - NP_002872
swissprot - C9J6B1
swissprot - A0A024RAG3
swissprot - C9JQB3
swissprot - C9JYR1
swissprot - P11234
swissprot - F8WEQ6
Ensembl - ENSG00000144118
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralbaENSDARG00000040778Danio rerio
 RALBENSGALG00000026493Gallus gallus
 RalbENSMUSG00000004451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RALA / P11233 / RAS like proto-oncogene AENSG0000000645183
RRAS2 / P62070 / RAS related 2ENSG0000013381846
RRAS / P10301 / RAS relatedENSG0000012645845
HRAS / P01112 / HRas proto-oncogene, GTPaseENSG0000017477544
NRAS / P01111 / NRAS proto-oncogene, GTPaseENSG0000021328144
KRAS / P01116 / KRAS proto-oncogene, GTPaseENSG0000013370342
MRAS / O14807 / muscle RAS oncogene homologENSG0000015818641
ERAS / Q7Z444 / ES cell expressed RasENSG0000018768235
GEM / P55040 / GTP binding protein overexpressed in skeletal muscleENSG0000016494932
RRAD / P55042 / RRAD, Ras related glycolysis inhibitor and calcium channel regulatorENSG0000016659231
RERG / Q96A58 / RAS like estrogen regulated growth inhibitorENSG0000013453331
REM2 / Q8IYK8 / RRAD and GEM like GTPase 2ENSG0000013989030
Q6T310 / RASL11A / RAS like family 11 member AENSG0000012203528
REM1 / O75628 / RRAD and GEM like GTPase 1ENSG0000008832028
Q9NYN1 / RASL12 / RAS like family 12ENSG0000010371028
Q9BPW5 / RASL11B / RAS like family 11 member BENSG0000012804522
RERGL / Q9H628 / RERG likeENSG0000011140420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028412  Ras-related protein Ral


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001928 regulation of exocyst assembly ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060178 regulation of exocyst localization ISS
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 biological_processGO:2000786 positive regulation of autophagosome assembly IMP
 cellular_componentGO:0000145 exocyst IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
p38MAPK events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000160271 Q12967 / RALGDS / ral guanine nucleotide dissociation stimulator  / reaction






 

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