ENSGALG00000003712


Gallus gallus

Features
Gene ID: ENSGALG00000003712
  
Biological name :RAPGEF1
  
Synonyms : RAPGEF1 / Rap guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology : Q13905 / Rap guanine nucleotide exchange factor (GEF) 1
  
Species: Gallus gallus
  
Chr. number: 17
Strand: -1
Band:
Gene start: 6717452
Gene end: 6765406
  
Corresponding Affymetrix probe sets: Gga.12144.1.S1_s_at (Chicken Array)   Gga.8935.1.S1_at (Chicken Array)   Gga.8935.2.S1_at (Chicken Array)   Gga.8935.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000005881
NCBI entrez gene - 417173     See in Manteia.
RefSeq - XM_015279742
RefSeq - XM_015279743
RefSeq - XM_015279744
RefSeq - XM_015279745
RefSeq - XM_015279746
RefSeq - XM_015279747
RefSeq - XM_015279748
RefSeq - XM_015279749
RefSeq - XM_015279750
RefSeq - XM_015279751
RefSeq - XM_015279752
RefSeq - XM_015279741
swissprot - E1BS61
Ensembl - ENSGALG00000003712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rapgef1aENSDARG00000043593Danio rerio
 Q13905ENSG00000107263Homo sapiens
 Rapgef1ENSMUSG00000039844Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOS2 / SOS Ras/Rho guanine nucleotide exchange factor 2 / Q02384* / Q07890* / Son of sevenless homolog 2 *ENSGALG0000001227321
SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *ENSGALG0000003945020
RASGRF1 / Ras protein specific guanine nucleotide releasing factor 1 / P27671* / Q13972*ENSGALG0000000826215
RASGRF2 / Ras protein specific guanine nucleotide releasing factor 2 / O14827* / ras-specific guanine nucleotide-releasing factor 2 *ENSGALG0000001559815
RGL4* / RGL2* / Q12967* / Q61193* / RALGDS* / Q8IZJ4* / O15211* / Q03385* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissociation stimulator li...ENSGALG0000000341211
RGL1 / ral guanine nucleotide dissociation stimulator like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSGALG0000000472810
Q5ZJK0 / RALGPS2 / Ras-specific guanine nucleotide-releasing factor RalGPS1 / Q9ERD6* / Q86X27* / Ral GEF with PH domain and SH3 binding motif 2*ENSGALG000000042737
RALGPS1 / Ral GEF with PH domain and SH3 binding motif 1 / A2AR50* / Q5JS13* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSGALG000000009067


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0038180 nerve growth factor signaling pathway IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1901888 regulation of cell junction assembly IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017034 Rap guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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