ENSGALG00000042125


Gallus gallus

Features
Gene ID: ENSGALG00000042125
  
Biological name :AP2B1
  
Synonyms : adaptor related protein complex 2 beta 1 subunit / AP2B1
  
Possible biological names infered from orthology : AP-2 complex subunit beta / P63010 / Q9DBG3
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 4367119
Gene end: 4427244
  
Corresponding Affymetrix probe sets: Gga.16538.1.S1_at (Chicken Array)   Gga.19003.1.S1_at (Chicken Array)   GgaAffx.20645.1.S1_s_at (Chicken Array)   GgaAffx.25408.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048833
NCBI entrez gene - 417525     See in Manteia.
RefSeq - XM_015296016
RefSeq - XM_415772
swissprot - A0A1D5P7Y8
Ensembl - ENSGALG00000042125
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap2b1ENSDARG00000035152Danio rerio
 AP2B1ENSG00000006125Homo sapiens
 Ap2b1ENSMUSG00000035152Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1B1 / adaptor related protein complex 1 beta 1 subunit / O35643* / Q10567* / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA.*ENSGALG0000004221385
AP4B1 / AP-4 complex subunit beta-1 / Q9WV76* / Q9Y6B7* / Gm43064* / adaptor related protein complex 4 beta 1 subunit*ENSGALG0000003529513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR012295  TBP domain superfamily
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0099590 neurotransmitter receptor internalization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003344 CLTB / clathrin light chain B / P09497* / Q6IRU5*  / reaction / complex
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / reaction / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex / reaction
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction
 ENSGALG00000004083 GRIA1 / glutamate ionotropic receptor AMPA type subunit 1 / P23818* / P42261* / Glutamate receptor 1 *  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex
 ENSGALG00000010166 VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*  / complex
 ENSGALG00000041823 PICK1 / protein interacting with PRKCA 1 / Q9NRD5* / protein interacting with C kinase 1*  / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000004594 CD74 / CD74 molecule / P04233* / P04441* / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)*  / complex
 ENSGALG00000034168 WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*  / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSGALG00000038995 GRIA4 / glutamate receptor 4 isoform 1 precursor / P48058* / Q9Z2W8* / glutamate receptor, ionotropic, AMPA4 (alpha 4)* / glutamate ionotropic receptor AMPA type subunit 4*  / reaction






 

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