ENSGALG00000017242


Gallus gallus

Features
Gene ID: ENSGALG00000017242
  
Biological name :FZD4
  
Synonyms : Frizzled-4 / FZD4 / Q9IA05
  
Possible biological names infered from orthology : frizzled class receptor 4 / Q61088 / Q9ULV1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 188780367
Gene end: 188784802
  
Corresponding Affymetrix probe sets: Gga.1941.1.S1_at (Chicken Array)   Gga.1941.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027820
NCBI entrez gene - 373887     See in Manteia.
RefSeq - NM_204099
RefSeq Peptide - NP_989430
swissprot - Q9IA05
Ensembl - ENSGALG00000017242
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FZD4ENSG00000174804Homo sapiens
 Fzd4ENSMUSG00000049791Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FZD10 / frizzled-10 precursor / Q9ULW2* / Q8BKG4* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000004200354
FZD9 / frizzled-9 precursor / Q9R216* / O00144* / Frizzled-9 * / frizzled class receptor 9*ENSGALG0000004192754
FZD10* / Q8BKG4* / Q9ULW2* / Frizzled-10 * / frizzled class receptor 10*ENSGALG0000000265252
FZD7 / frizzled class receptor 7 / O75084* / Q61090* / Frizzled-7 *ENSGALG0000003497344
FZD2 / frizzled-2 precursor / Q9JIP6* / Q14332* / Frizzled-2 * / frizzled class receptor 2*ENSGALG0000003084744
FZD1 / frizzled-1 precursor / Q9UP38* / O70421* / Frizzled-1 * / frizzled class receptor 1*ENSGALG0000000906444
FZD5 / frizzled class receptor 5 / Q13467* / Q9EQD0* / Frizzled-5 *ENSGALG0000003410142
FZD8 / frizzled class receptor 8 / Q61091* / Q9H461* / Frizzled-8 *ENSGALG0000003999942
FZD3 / frizzled class receptor 3 / Q61086* / Q9NPG1* / Frizzled-3 *ENSGALG0000004230833
FZD6 / frizzled-6 precursor / Q61089* / O60353* / Frizzled-6 * / frizzled class receptor 6*ENSGALG0000003062631
SMO / smoothened, frizzled class receptor / P56726* / Q99835*ENSGALG0000003611424
SFRP1 / secreted frizzled related protein 1 / Q8C4U3* / Q8N474*ENSGALG0000000347314
SFRP4 / secreted frizzled related protein 4 / Q6FHJ7* / Q9Z1N6*ENSGALG0000003199714
FRZB / secreted frizzled-related protein 3 precursor / P97401* / Q92765* / frizzled related protein* / Secreted frizzled-related protein 3 *ENSGALG0000000276314
SFRP2 / secreted frizzled-related protein 2 precursor / P97299* / Q96HF1* / secreted frizzled related protein 2*ENSGALG0000000924113
ENSGALG0000000863513
crescent precursor ENSGALG0000000694412
SFRP5 / Gallus gallus secreted frizzled related protein 5 (SFRP5), mRNA. / Q5T4F7* / secreted frizzled related protein 5* / secreted frizzled-related sequence protein 5*ENSGALG0000000751512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000539  Frizzled/Smoothened, transmembrane domain
 IPR015526  Frizzled/secreted frizzled-related protein
 IPR017981  GPCR, family 2-like
 IPR020067  Frizzled domain
 IPR026551  Frizzled-4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001553 luteinization ISO
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007223 Wnt signaling pathway, calcium modulating pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IEA
 biological_processGO:0016055 Wnt signaling pathway ISO
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0031987 locomotion involved in locomotory behavior ISO
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISO
 biological_processGO:0035426 extracellular matrix-cell signaling ISO
 biological_processGO:0035567 non-canonical Wnt signaling pathway IBA
 biological_processGO:0042701 progesterone secretion ISO
 biological_processGO:0043507 positive regulation of JUN kinase activity ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IEA
 biological_processGO:0061301 cerebellum vasculature morphogenesis ISO
 biological_processGO:0061304 retinal blood vessel morphogenesis IEA
 biological_processGO:0150012 positive regulation of neuron projection arborization IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0070062 extracellular exosome ISO
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0017147 Wnt-protein binding ISO
 molecular_functionGO:0019955 cytokine binding ISO
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0038023 signaling receptor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Ca2+ pathway
Asymmetric localization of PCP proteins
Regulation of FZD by ubiquitination
WNT5A-dependent internalization of FZD4


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / complex / reaction
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / complex
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000034168 WNT5A / Wnt family member 5A / P22725* / P41221* / wingless-type MMTV integration site family, member 5A*  / complex / reaction
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

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