ENSMUSG00000001300


Mus musculus

Features
Gene ID: ENSMUSG00000001300
  
Biological name :Efnb2
  
Synonyms : Efnb2 / Ephrin-B2 / P52800
  
Possible biological names infered from orthology : P52799
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 8617434
Gene end: 8661242
  
Corresponding Affymetrix probe sets: 10576911 (MoGene1.0st)   1419638_at (Mouse Genome 430 2.0 Array)   1419639_at (Mouse Genome 430 2.0 Array)   1449548_at (Mouse Genome 430 2.0 Array)   1449549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001319
Ensembl peptide - ENSMUSP00000116027
NCBI entrez gene - 13642     See in Manteia.
MGI - MGI:105097
RefSeq - XM_011242036
RefSeq - NM_010111
RefSeq - XM_006508694
RefSeq Peptide - NP_034241
swissprot - P52800
swissprot - Q4FJM3
swissprot - F6RSU6
Ensembl - ENSMUSG00000001300
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb2aENSDARG00000020164Danio rerio
 efnb2bENSDARG00000074050Danio rerio
 EFNB2ENSGALG00000029175Gallus gallus
 EFNB2ENSG00000125266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efnb1 / P52795 / Ephrin-B1 / P98172*ENSMUSG0000003121752
Efnb3 / O35393 / Ephrin-B3 / Q15768*ENSMUSG0000000393441


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0010977 negative regulation of neuron projection development ISO
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0050920 regulation of chemotaxis ISS
 biological_processGO:0072178 nephric duct morphogenesis IMP
 biological_processGO:1901216 positive regulation of neuron death ISO
 biological_processGO:1903849 positive regulation of aorta morphogenesis IMP
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding ISO


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Atrtm1Akl/Atrtm1Akl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2+,Rbpjtm1Kyo/Rbpjtm1Kyo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tcof1tm1Mjd/Tcof1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0000424 retarded hair growth "slow growth of the hair, appears at normal time" [J:5476]
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Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0000537 abnormal urethra morphology "anomalous structure of the canal leading from the bladder, discharging the urine externally" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0000618 small salivary gland "reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
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Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
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Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Uacatm1Kiy/Uacatm1Kiy
Genetic Background: B6.129P2-Uacatm1Kiy

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcof1tm1Mjd/Tcof1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Atrtm1Akl/Atrtm1Akl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: CD-1

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln,Flt4tm1Ali/Flt4+
Genetic Background: involves: C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: CD-1

Allelic Composition: Efnb2tm2.1Henk/Efnb2tm2.1Henk
Genetic Background: involves: 129 * CD-1

Allelic Composition: Efnb2tm3.1Henk/Efnb2tm3.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0002349 abnormal afferent lymphatic vessel morphology "structural anomaly in the tube entering the lymph node" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln,Flt4tm1Ali/Flt4+
Genetic Background: involves: C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003124 hypospadia "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw,Ephb3tm1Kln/Ephb3+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Henk/Efnb2+,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Henk/Efnb2tm2.1Henk
Genetic Background: involves: 129 * CD-1

Allelic Composition: Efnb2tm1Henk/Efnb2tm3.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003125 abnormal septation of the cloaca "absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into mutliple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0003128 splayed clitoris "flattened or spread out clitoris" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0003129 persistent cloaca "the presence of a single external opening to which the urinary, digestive and reproductive tracts all connect" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003130 anal atresia "absence of a connection between the anal pit and the rectum" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0003164 reduced size of posterior semicircular canal 
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0003166 reduced size of superior semicircular canal 
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

 MP:0003321 tracheoesophageal fistula "an abnormal passage between the esophagus and the trachea, acquired or congenital, often associated with esophageal atresia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
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Allelic Composition: Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic Background: involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: C57BL/6

 MP:0003660 chylothorax "an accumulation of chyle (fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels) in the thoracic cavity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95585]
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Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm5Kln/Efnb2tm5Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: CD-1

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004126 thin hypodermis "reduced thickness of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0004783 abnormal cardinal vein morphology "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004784 abnormal anterior cardinal vein morphology "any structural anomaly of the two paired veins draining the cephalic part of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004885 abnormal endolymph "any alteration in the normal production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear; unlike perilymph, endolymph resembles intracellular fluid in composition and has a high concentration of potassium ion and a low concentration of sodium ion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0004887 decreased endolymph production "reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005187 abnormal penis morphology "anomalous structure of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005189 abnormal anogenital distance "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
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Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk,Efnb2tm3.1Henk/Efnb2tm3.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: Not Specified

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0006012 dilated endolymphatic duct "an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0006014 dilated endolymphatic sac "an expansion in the volume of the endolymphatic sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0006338 abnormal second branchial arch morphology "anomaly in the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006389 abnormal vestibular endolymph "change in the normal production (volume) or ionic homeostasis of the fluid contained within the vestibule of the inner ear; unlike cochlear endolymph this fluid does not have a high potential" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0006391 abnormal vestibular endolymph ionic homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the vestibular endolymph" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0008066 small endolymphatic duct "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrctm1Blk/Hrc+
Genetic Background: B6.129S6-Hrctm1Blk

Allelic Composition: Efnb2tm1Henk/Efnb2+
Genetic Background: involves: 129 * CD-1

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008530 abnormal rostral-caudal patterning of the somites "anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1Sor/Efnb2tm1Sor
Genetic Background: 129S4/SvJaeSor-Efnb2tm1Sor

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0010600 enlarged pulmonary valve "an increase in the total area occupied by the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0010617 thick mitral valve cusps 
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0010860 abnormal anterior commissure pars posterior morphology "any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Efnb2tm5.1Kln/Efnb2tm5.1Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm5Kln/Efnb2tm5Kln
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb2tm2And/Efnb2tm2And,Tg(CAG-cre/Esr1*)1Egwa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

Allelic Composition: Efnb2tm1Henk/Efnb2tm1Henk
Genetic Background: involves: 129 * CD-1

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gria4tm1Dgen/Gria4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1.1Henk/Efnb2tm1.1Henk
Genetic Background: either: 129 or (involves: 129 * C57BL/6) or (involves: 129 * CD-1)

Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Pim1tm1Pwl/Pim1tm1Pwl,Pim2tm1Brn/Pim2tm1Brn,Pim3tm1Brn/Pim3tm1Brn
Genetic Background: involves: 129P/Ola * FVB/N

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
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Allelic Composition: Efnb2tm1And/Efnb2tm2And,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1And/Efnb2tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Efnb2tm3.1Kln/Efnb2tm3.1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012493 absent branchial arch arteries "absence of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [MGI:anna]
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Allelic Composition: Efnb2tm1Kln/Efnb2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012755 decreased cranial neural crest cell number "reduction in the number of neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0012761 increased cranial neural crest cell apoptosis "increased number of cranial neural crest cells (NCCs) undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0013012 abnormal trunk neural crest cell migration "any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the trunk neural crest which lies between the vagal and sacral neural crest; there are two major pathways taken by the migrating trunk NCCs: (1) one group of cells fated to become melanocytes (the melanin-forming pigment cells) migrates dorsolaterally into the ectoderm towards the ventral midline and colonizes the skin and hair follicles; (2) a second group of cells migrates ventrolaterally through the anterior portion of each sclerotome; the cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons, whereas those that continue more ventrally form the sympathetic ganglia, chromaffin cells of the adrenal medulla, Schwann (precursor) cells, and the nerve clusters surrounding the aorta" [http://www.ncbi.nlm.nih.gov/books/NBK10065/, MGI:anna]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / - / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / - / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / - / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex / - / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction / -
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex / -
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / reaction / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000028249 Sdcbp / O08992 / syndecan binding protein / O00560*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction / -
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / complex / reaction
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex






 

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