ENSG00000125266


Homo sapiens

Features
Gene ID: ENSG00000125266
  
Biological name :EFNB2
  
Synonyms : EFNB2 / ephrin B2 / P52799
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q33.3
Gene start: 106489731
Gene end: 106535662
  
Corresponding Affymetrix probe sets: 202668_at (Human Genome U133 Plus 2.0 Array)   202669_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000245323
Ensembl peptide - ENSP00000493716
NCBI entrez gene - 1948     See in Manteia.
OMIM - 600527
RefSeq - XM_017020406
RefSeq - NM_004093
RefSeq Peptide - NP_004084
swissprot - P52799
Ensembl - ENSG00000125266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb2aENSDARG00000020164Danio rerio
 efnb2bENSDARG00000074050Danio rerio
 EFNB2ENSGALG00000029175Gallus gallus
 Efnb2ENSMUSG00000001300Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNB1 / P98172 / ephrin B1ENSG0000009077654
EFNB3 / Q15768 / ephrin B3ENSG0000010894741


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0050920 regulation of chemotaxis IDA
 biological_processGO:0072178 nephric duct morphogenesis IMP
 biological_processGO:1901216 positive regulation of neuron death IDA
 biological_processGO:1903849 positive regulation of aorta morphogenesis IMP
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000169439 SDC2 / P34741 / syndecan 2  / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / - / complex
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / - / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex / -
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / reaction / complex
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000137575 SDCBP / O00560 / syndecan binding protein  / complex / reaction
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000214944 Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28  / reaction / complex
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / complex / reaction
 ENSG00000145715 RASA1 / P20936 / RAS p21 protein activator 1  / reaction / complex
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / reaction / complex
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000205726 ITSN1 / Q15811 / intersectin 1  / reaction / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction






 

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