ENSG00000108262


Homo sapiens

Features
Gene ID: ENSG00000108262
  
Biological name :GIT1
  
Synonyms : GIT1 / GIT ArfGAP 1 / Q9Y2X7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q11.2
Gene start: 29573469
Gene end: 29594054
  
Corresponding Affymetrix probe sets: 218030_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463746
Ensembl peptide - ENSP00000466824
Ensembl peptide - ENSP00000464933
Ensembl peptide - ENSP00000464388
Ensembl peptide - ENSP00000225394
Ensembl peptide - ENSP00000334125
Ensembl peptide - ENSP00000378338
Ensembl peptide - ENSP00000462775
Ensembl peptide - ENSP00000463435
Ensembl peptide - ENSP00000463543
NCBI entrez gene - 28964     See in Manteia.
OMIM - 608434
RefSeq - XM_011524684
RefSeq - XM_011524685
RefSeq - NM_014030
RefSeq - NM_001085454
RefSeq Peptide - NP_054749
RefSeq Peptide - NP_001078923
swissprot - E7EVC2
swissprot - Q9Y2X7
swissprot - K7EN79
swissprot - A0A0C4DGN6
swissprot - J3QL89
swissprot - J3QLH1
swissprot - J3QQI0
swissprot - J3QRU8
swissprot - K7EIX6
Ensembl - ENSG00000108262
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 git1ENSDARG00000039489Danio rerio
 GIT1ENSGALG00000023703Gallus gallus
 Git1ENSMUSG00000011877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GIT2 / Q14161 / GIT ArfGAP 2ENSG0000013943665


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR002110  Ankyrin repeat
 IPR013724  GIT, Spa2 homology (SHD) domain
 IPR020683  Ankyrin repeat-containing domain
 IPR022018  ARF GTPase-activating protein GIT1, C-terminal
 IPR032352  Arf GTPase-activating protein GIT1/2, coiled-coil domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0032465 regulation of cytokinesis IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex






 

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