ENSGALG00000023703


Gallus gallus

Features
Gene ID: ENSGALG00000023703
  
Biological name :GIT1
  
Synonyms : GIT1 / GIT ArfGAP 1
  
Possible biological names infered from orthology : ARF GTPase-activating protein GIT1 / Q68FF6 / Q9Y2X7
  
Species: Gallus gallus
  
Chr. number: 19
Strand: -1
Band:
Gene start: 6062311
Gene end: 6070062
  
Corresponding Affymetrix probe sets: Gga.921.1.S1_at (Chicken Array)   GgaAffx.21656.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049226
Ensembl peptide - ENSGALP00000052463
Ensembl peptide - ENSGALP00000038832
NCBI entrez gene - 417584     See in Manteia.
RefSeq - XM_015295770
RefSeq - NM_204296
RefSeq - XM_015295768
RefSeq - XM_015295769
RefSeq Peptide - NP_989627
swissprot - Q9DG15
swissprot - A0A1D5PI31
swissprot - A0A1D5P926
Ensembl - ENSGALG00000023703
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 git1ENSDARG00000039489Danio rerio
 GIT1ENSG00000108262Homo sapiens
 Git1ENSMUSG00000011877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GIT2 / ARF GTPase-activating protein GIT2 / Q14161* / Q9JLQ2* / GIT ArfGAP 2*ENSGALG0000004084466


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR002110  Ankyrin repeat
 IPR013724  GIT, Spa2 homology (SHD) domain
 IPR020683  Ankyrin repeat-containing domain
 IPR022018  ARF GTPase-activating protein GIT1, C-terminal
 IPR032352  Arf GTPase-activating protein GIT1/2, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0032587 ruffle membrane IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000008058 PAK3 / p21 (RAC1) activated kinase 3 / O75914* / Q61036* / Serine/threonine-protein kinase PAK 3 *  / complex / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / reaction / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction / complex
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / reaction / complex






 

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