ENSG00000169439


Homo sapiens

Features
Gene ID: ENSG00000169439
  
Biological name :SDC2
  
Synonyms : P34741 / SDC2 / syndecan 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q22.1
Gene start: 96493351
Gene end: 96611780
  
Corresponding Affymetrix probe sets: 212154_at (Human Genome U133 Plus 2.0 Array)   212157_at (Human Genome U133 Plus 2.0 Array)   212158_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429121
Ensembl peptide - ENSP00000427784
Ensembl peptide - ENSP00000429662
Ensembl peptide - ENSP00000307046
Ensembl peptide - ENSP00000429045
Ensembl peptide - ENSP00000428256
NCBI entrez gene - 6383     See in Manteia.
OMIM - 142460
RefSeq - NM_002998
RefSeq - XM_011517212
RefSeq Peptide - NP_002989
swissprot - E5RHU3
swissprot - E9PBI9
swissprot - P34741
swissprot - A0A024R9D1
swissprot - E7ESK6
swissprot - E5RJB8
Ensembl - ENSG00000169439
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdc2ENSDARG00000002731Danio rerio
 SDC2ENSGALG00000031424Gallus gallus
 Sdc2ENSMUSG00000022261Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SDC3 / O75056 / syndecan 3ENSG0000016251238
SDC4 / P31431 / syndecan 4ENSG0000012414535
SDC1 / P18827 / syndecan 1ENSG0000011588434


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031201  Syndecan-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006024 glycosaminoglycan biosynthetic process TAS
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0008218 bioluminescence IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030203 glycosaminoglycan metabolic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048813 dendrite morphogenesis IBA
 biological_processGO:0048814 regulation of dendrite morphogenesis ISS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0043202 lysosomal lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPHB-mediated forward signaling
Defective B3GALT6 causes EDSP2 and SEMDJL1
Post-translational protein phosphorylation
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction
 ENSG00000169439 SDC2 / P34741 / syndecan 2  / -






 

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