ENSG00000176105


Homo sapiens

Features
Gene ID: ENSG00000176105
  
Biological name :YES1
  
Synonyms : P07947 / YES1 / YES proto-oncogene 1, Src family tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: p11.32
Gene start: 721588
Gene end: 812546
  
Corresponding Affymetrix probe sets: 202932_at (Human Genome U133 Plus 2.0 Array)   202933_s_at (Human Genome U133 Plus 2.0 Array)   210917_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324740
Ensembl peptide - ENSP00000462468
Ensembl peptide - ENSP00000464380
NCBI entrez gene - 7525     See in Manteia.
OMIM - 164880
RefSeq - XM_017025960
RefSeq - NM_005433
RefSeq - XM_005258139
RefSeq Peptide - NP_005424
swissprot - P07947
swissprot - J3QRU1
Ensembl - ENSG00000176105
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yes1ENSDARG00000005941Danio rerio
 YES1ENSGALG00000014860Gallus gallus
 Yes1ENSMUSG00000014932Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712275
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081073
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093868
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133658
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408754
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286654
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657353
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181644
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121336
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550835


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035751  Tyrosine-protein kinase Yes, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043114 regulation of vascular permeability TAS
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0044325 ion channel binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / reaction / complex
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000066248 NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex






 

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