ENSG00000066248


Homo sapiens

Features
Gene ID: ENSG00000066248
  
Biological name :NGEF
  
Synonyms : neuronal guanine nucleotide exchange factor / NGEF / Q8N5V2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.1
Gene start: 232878686
Gene end: 233013272
  
Corresponding Affymetrix probe sets: 227240_at (Human Genome U133 Plus 2.0 Array)   243556_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401063
Ensembl peptide - ENSP00000387591
Ensembl peptide - ENSP00000405053
Ensembl peptide - ENSP00000264051
Ensembl peptide - ENSP00000362653
Ensembl peptide - ENSP00000387033
NCBI entrez gene - 25791     See in Manteia.
OMIM - 605991
RefSeq - XM_011510925
RefSeq - NM_001114090
RefSeq - NM_019850
RefSeq - XM_011510923
RefSeq - XM_011510924
RefSeq Peptide - NP_001107562
RefSeq Peptide - NP_062824
swissprot - H7BZ39
swissprot - H7C2C2
swissprot - Q8N5V2
swissprot - C9JTV7
Ensembl - ENSG00000066248
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngefENSDARG00000076179Danio rerio
 NGEFENSGALG00000036327Gallus gallus
 NgefENSMUSG00000026259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032735
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263232
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884428
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479027
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035635  Ephexin-1, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction / complex






 

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