ENSG00000114790


Homo sapiens

Features
Gene ID: ENSG00000114790
  
Biological name :ARHGEF26
  
Synonyms : ARHGEF26 / Q96DR7 / Rho guanine nucleotide exchange factor 26
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.2
Gene start: 154121003
Gene end: 154257827
  
Corresponding Affymetrix probe sets: 222121_at (Human Genome U133 Plus 2.0 Array)   227197_at (Human Genome U133 Plus 2.0 Array)   233903_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424446
Ensembl peptide - ENSP00000348828
Ensembl peptide - ENSP00000423295
Ensembl peptide - ENSP00000423418
NCBI entrez gene - 26084     See in Manteia.
OMIM - 617552
RefSeq - XM_017006160
RefSeq - NM_001251962
RefSeq - NM_001251963
RefSeq - NM_015595
RefSeq - XM_011512672
RefSeq Peptide - NP_001238892
RefSeq Peptide - NP_056410
RefSeq Peptide - NP_001238891
swissprot - Q96DR7
swissprot - A0A140VJU4
Ensembl - ENSG00000114790
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF26ENSGALG00000010352Gallus gallus
 Arhgef26ENSMUSG00000036885Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076236
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032727
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263224
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884422
NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factorENSG0000006624822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035797  ARHGEF16/ARHGEF26, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0097178 ruffle assembly IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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