ENSG00000050327


Homo sapiens

Features
Gene ID: ENSG00000050327
  
Biological name :ARHGEF5
  
Synonyms : ARHGEF5 / Q12774 / Rho guanine nucleotide exchange factor 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q35
Gene start: 144355288
Gene end: 144380632
  
Corresponding Affymetrix probe sets: 204765_at (Human Genome U133 Plus 2.0 Array)   228596_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417979
Ensembl peptide - ENSP00000418745
Ensembl peptide - ENSP00000418227
Ensembl peptide - ENSP00000056217
NCBI entrez gene - 7984     See in Manteia.
OMIM - 600888
RefSeq - NM_005435
RefSeq - XM_017012623
RefSeq Peptide - NP_005426
swissprot - H0Y895
swissprot - C9J591
swissprot - Q12774
swissprot - A0A090N7S2
Ensembl - ENSG00000050327
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000017276Gallus gallus
 E9Q7D5ENSMUSG00000033542Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263221
NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factorENSG0000006624816
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479015
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884415
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029212  Rho guanine nucleotide exchange factor 5/35, N-terminal
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002408 myeloid dendritic cell chemotaxis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051493 regulation of cytoskeleton organization IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:1904591 positive regulation of protein import IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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