ENSMUSG00000033542


Mus musculus

Features
Gene ID: ENSMUSG00000033542
  
Biological name :Arhgef5
  
Synonyms : Arhgef5 / E9Q7D5 / Rho guanine nucleotide exchange factor 5
  
Possible biological names infered from orthology : Q12774
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.1
Gene start: 43265582
Gene end: 43289320
  
Corresponding Affymetrix probe sets: 10537834 (MoGene1.0st)   10537849 (MoGene1.0st)   1452304_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138192
Ensembl peptide - ENSMUSP00000031750
NCBI entrez gene - 54324     See in Manteia.
MGI - MGI:1858952
RefSeq - NM_133674
RefSeq - XM_006506387
RefSeq Peptide - NP_598435
swissprot - E9Q7D5
swissprot - S4R1F1
Ensembl - ENSMUSG00000033542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000017276Gallus gallus
 Q12774ENSG00000050327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BWA8 / Arhgef19 / Rho guanine nucleotide exchange factor 19 / Q8IW93*ENSMUSG0000002891921
Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*ENSMUSG0000002625916
Q5FWH6 / Arhgef15 / Rho guanine nucleotide exchange factor 15 / O94989*ENSMUSG0000005292116
Arhgef26 / Rho guanine nucleotide exchange factor (GEF) 26 / Q96DR7* / Rho guanine nucleotide exchange factor 26*ENSMUSG0000003688515
Q3U5C8 / Arhgef16 / Rho guanine nucleotide exchange factor 16 / Q5VV41*ENSMUSG0000002903214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029212  Rho guanine nucleotide exchange factor 5/35, N-terminal
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002408 myeloid dendritic cell chemotaxis IMP
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0071803 positive regulation of podosome assembly IGI
 biological_processGO:1904591 positive regulation of protein import IEA
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0004997 increased CNS synapse formation "greater frequency of the process of generating the initial connections between an axon and effector tissue or neuron " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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