ENSMUSG00000052921


Mus musculus

Features
Gene ID: ENSMUSG00000052921
  
Biological name :Arhgef15
  
Synonyms : Arhgef15 / Q5FWH6 / Rho guanine nucleotide exchange factor 15
  
Possible biological names infered from orthology : O94989
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 68943155
Gene end: 68957480
  
Corresponding Affymetrix probe sets: 10387201 (MoGene1.0st)   1440358_at (Mouse Genome 430 2.0 Array)   1455522_at (Mouse Genome 430 2.0 Array)   1457172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067684
Ensembl peptide - ENSMUSP00000104311
NCBI entrez gene - 442801     See in Manteia.
MGI - MGI:3045246
RefSeq - XM_017314643
RefSeq - NM_177566
RefSeq - XM_011249121
RefSeq - XM_011249122
RefSeq - XM_006533664
RefSeq - XM_006533666
RefSeq - XM_006533669
RefSeq - XM_011249109
RefSeq - XM_011249110
RefSeq - XM_011249111
RefSeq - XM_011249112
RefSeq - XM_011249113
RefSeq - XM_011249114
RefSeq - XM_011249115
RefSeq - XM_011249116
RefSeq - XM_011249117
RefSeq - XM_011249118
RefSeq - XM_011249119
RefSeq - XM_011249120
RefSeq Peptide - NP_808234
swissprot - Q5FWH6
Ensembl - ENSMUSG00000052921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef15ENSDARG00000100293Danio rerio
 si:dkey-38p12.3ENSDARG00000061844Danio rerio
 O94989ENSG00000198844Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q7D5 / Arhgef5 / Rho guanine nucleotide exchange factor 5 / Q12774*ENSMUSG0000003354229
Q8BWA8 / Arhgef19 / Rho guanine nucleotide exchange factor 19 / Q8IW93*ENSMUSG0000002891925
Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*ENSMUSG0000002625924
Arhgef26 / Rho guanine nucleotide exchange factor (GEF) 26 / Q96DR7* / Rho guanine nucleotide exchange factor 26*ENSMUSG0000003688522
Q3U5C8 / Arhgef16 / Rho guanine nucleotide exchange factor 16 / Q5VV41*ENSMUSG0000002903221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity ISS
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IMP
 biological_processGO:2000297 negative regulation of synapse maturation IMP
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

Allelic Composition: Arhgef15tm1Nmoc/Arhgef15tm1Nmoc
Genetic Background: B6.Cg-Arhgef15tm1Nmoc

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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