ENSMUSG00000026259


Mus musculus

Features
Gene ID: ENSMUSG00000026259
  
Biological name :Ngef
  
Synonyms : Ephexin-1 / Ngef / Q8CHT1
  
Possible biological names infered from orthology : neuronal guanine nucleotide exchange factor / Q8N5V2
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: D
Gene start: 87476834
Gene end: 87573870
  
Corresponding Affymetrix probe sets: 10356406 (MoGene1.0st)   1448978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127674
Ensembl peptide - ENSMUSP00000027477
Ensembl peptide - ENSMUSP00000066894
NCBI entrez gene - 53972     See in Manteia.
MGI - MGI:1858414
RefSeq - NM_019867
RefSeq - NM_001111314
RefSeq Peptide - NP_001104784
RefSeq Peptide - NP_063920
swissprot - Q8CHT1
swissprot - F6SWQ9
swissprot - E9QK62
Ensembl - ENSMUSG00000026259
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngefENSDARG00000076179Danio rerio
 NGEFENSGALG00000036327Gallus gallus
 NGEFENSG00000066248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q7D5 / Arhgef5 / Rho guanine nucleotide exchange factor 5 / Q12774*ENSMUSG0000003354235
Q8BWA8 / Arhgef19 / Rho guanine nucleotide exchange factor 19 / Q8IW93*ENSMUSG0000002891931
Q5FWH6 / Arhgef15 / Rho guanine nucleotide exchange factor 15 / O94989*ENSMUSG0000005292128
Q3U5C8 / Arhgef16 / Rho guanine nucleotide exchange factor 16 / Q5VV41*ENSMUSG0000002903227
Arhgef26 / Rho guanine nucleotide exchange factor (GEF) 26 / Q96DR7* / Rho guanine nucleotide exchange factor 26*ENSMUSG0000003688526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035635  Ephexin-1, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009987 cellular process IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Nrp1tm1Hfu/Nrp1tm1Hfu
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026235 Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex






 

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